Paraneoplastic Limbic Encephalitis Caused by Ovarian Teratoma with Autoantibodies to Glutamate Receptor

被引：12

作者：

Okamoto, Sadahisa ^{[1
]}

Hirano, Teruyuki ^{[1
]}

Takahashi, Yukitoshi ^{[2
]}

Yamashita, Taro ^{[1
]}

Uyama, Eiichiro ^{[1
]}

Uchino, Makoto ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Kumamoto, Japan

[2] Shizuoka Inst Epilepsy & Neurol Disorders, Natl Epilepsy Ctr, Shizuoka, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 13期

关键词：

paraneoplastic limbic encephalitis; ovarian teratoma; glutamate receptor;

D O I：

10.2169/internalmedicine.46.6466

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a rare case of paraneoplastic limbic encephalitis with autoantibodies to glutamate receptor (GluR) in the cerebrospinal fluid (CSF). The 35-year-old woman with consciousness disturbance was diagnosed initially as non-herpetic encephalitis. Her signs and symptoms improved with acyclovir and steroid pulse therapy. However, after the treatment, an ovarian tumor was discovered, and we detected autoantibodies to GluR in the CSF. A possible association between the ovarian teratoma and GluR is suggested.

引用

页码：1019 / 1022

页数：4

共 14 条

[1] Non-herpetic acute limbic encephalitis: Cerebrospinal fluid cytokines and magnetic resonance imaging findings [J].

Asaoka, K ;

Shoji, H ;

Nishizaka, S ;

Ayabe, M ;

Abe, T ;

Ohori, N ;

Ichiyama, T ;

Eizuru, Y .

INTERNAL MEDICINE, 2004, 43 (01) :42-48

[2] Paraneoplastic limbic encephalitis with immature ovarian teratoma - A case report [J].

Aydiner, A ;

Gurvit, H ;

Baral, I .

JOURNAL OF NEURO-ONCOLOGY, 1998, 37 (01) :63-66

[3]

DALMAU J, 1997, CANC NERVOUS SYSTEM, P674

[4] A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus [J].

DeGiorgio, LA ;

Konstantinov, KN ;

Lee, SC ;

Hardin, JA ;

Volpe, BT ;

Diamond, B .

NATURE MEDICINE, 2001, 7 (11) :1189-1193

[5]

Fadare Oluwole, 2004, Int Semin Surg Oncol, V1, P11, DOI 10.1186/1477-7800-1-11

[6]

Hayashi Yuichi, 2005, Rinsho Shinkeigaku, V45, P657

[7]

MUNAKATA S, 2003, SHINKEINAIKA, V59, P112

[8] Reversible limbic encephalitis caused by ovarian teratoma [J].

Nokura, K ;

Yamamoto, H ;

Okawara, Y ;

Koga, H ;

Osawa, H ;

Sakai, K .

ACTA NEUROLOGICA SCANDINAVICA, 1997, 95 (06) :367-373

[9] An acutely confused 15-year-old girl [J].

Okamura, H ;

Oomori, N ;

Uchitomi, Y .

LANCET, 1997, 350 (9076) :488-488

[10] Acute viral encephalitis: The recent progress [J].

Shoji, H ;

Azuma, K ;

Nishimura, Y ;

Fujimoto, H ;

Sugita, Y ;

Eizuru, Y .

INTERNAL MEDICINE, 2002, 41 (06) :420-428

← 1 2 →