CXCR4 in Epidermal Keratinocytes: Crosstalk within the Skin

被引：23

作者：

Bollag, Wendy B. ^{[1
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Hill, William D. ^{[1
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机构：

[1] Charlie Norwood VA Med Ctr, Augusta, GA USA

[2] Georgia Regents Univ, Dept Physiol, Med Coll Georgia, Augusta, GA 30912 USA

[3] Georgia Regents Univ, Dept Med Dermatol, Med Coll Georgia, Augusta, GA 30912 USA

[4] Georgia Regents Univ, Dept Cellular Biol & Anat, Med Coll Georgia, Augusta, GA 30912 USA

[5] Georgia Regents Univ, Dept Orthopaed Surg, Med Coll Georgia, Augusta, GA 30912 USA

[6] Georgia Regents Univ, Inst Regenerat & Reparat Med, Med Coll Georgia, Augusta, GA 30912 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2013年 / 133卷 / 11期

关键词：

FACTOR-I; CELL MOBILIZATION; PROLIFERATION; EXPRESSION; AMD3100; SDF-1; AXIS;

D O I：

10.1038/jid.2013.271

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.

引用

收藏

页码：2505 / 2508

页数：4

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