Iron/sulfur proteins biogenesis in prokaryotes: Formation, regulation and diversity

被引:237
作者
Roche, Beatrice [1 ]
Aussel, Laurent [1 ]
Ezraty, Benjamin [1 ]
Mandin, Pierre [1 ]
Py, Beatrice [1 ]
Barras, Frederic [1 ]
机构
[1] Aix Marseille Univ, Inst Microbiol Mediterranee, Chim Bacterienne Lab, CNRS,UMR 7283, F-13009 Marseille, France
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2013年 / 1827卷 / 03期
关键词
Fe-S cluster biosynthesis; Fe-S cluster homeostasis; Fe-S regulation; Fe-S domains; Fe-S cluster and pathogens; Metal toxicity; IRON-SULFUR CLUSTER; FE-S CLUSTER; MONOTHIOL GLUTAREDOXINS FUNCTION; CYSTEINE SULFINATE DESULFINASE; ESCHERICHIA-COLI; SCAFFOLD PROTEIN; OXIDATIVE STRESS; 4FE-4S CLUSTERS; HYDROGEN-PEROXIDE; PSEUDOMONAS-AERUGINOSA;
D O I
10.1016/j.bbabio.2012.12.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Iron/sulfur centers are key cofactors of proteins intervening in multiple conserved cellular processes, such as gene expression, DNA repair, RNA modification, central metabolism and respiration. Mechanisms allowing Fe/S centers to be assembled, and inserted into polypeptides have attracted much attention in the last decade, both in eukaryotes and prokaryotes. Basic principles and recent advances in our understanding of the prokaryotic Fe/S biogenesis ISC and SUF systems are reviewed in the present communication. Most studies covered stem from investigations in Escherichia coli and Azotobacter vinelandii. Remarkable insights were brought about by complementary structural, spectroscopic, biochemical and genetic studies. Highlights of the recent years include scaffold mediated assembly of Fe/S cluster, A-type carriers mediated delivery of clusters and regulatory control of Fe/S homeostasis via a set of interconnected genetic regulatory circuits. Also, the importance of Fe/S biosynthesis systems in mediating soft metal toxicity was documented. A brief account of the Fe/S biosynthesis systems diversity as present in current databases is given here. Moreover, Fe/S biosynthesis factors have themselves been the object of molecular tailoring during evolution and some examples are discussed here. An effort was made to provide, based on the E. coli system, a general classification associating a given domain with a given function such as to help next search and annotation of genomes. This article is part of a Special Issue entitled: Metals in Bioenergetics and Biomimetics Systems. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:455 / 469
页数:15
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