Transversus abdominis plane (TAP) block has been shown to provide pain relief after abdominal procedures. However, TAP block combined with multimodal analgesia technique have not been assessed in a randomized controlled trial. This randomized, controlled, observer-blinded study was designed to evaluate the analgesic efficacy of bilateral ultrasound-guided TAP blocks with or without acetaminophen and non-steroidal anti-inflammatory drug (NSAID) combination. Patients undergoing total abdominal hysterectomy were randomized to one of three groups. Group 1 (n = 25) received a TAP block and ketorolac 30 mg, IV at the end of surgery and then ketorolac plus paracetamol 650 mg, orally, every 6 h for 24 h. Group 2 (n = 24) received only TAP block at the end of surgery. Group 3 (n = 25) received ketorolac 30 mg, IV at the end of surgery and then ketorolac plus paracetamol 650 mg, orally, every 6 h for 24 h. All patients received IV-PCA morphine for 24-h, postoperatively. All patients received a standardized general anaesthetic technique and dexamethasone 4 mg and ondansetron 4 mg, IV for antiemetic prophylaxis. There were no statistically significant differences in pain at rest between the groups. However, the pain on coughing (dynamic pain) in Group 1 was significantly less variable, compared with the other two groups (P = 0.012). Opioid consumption and occurrences of nausea, vomiting, and rescue antiemetic were similar in three the groups. The combination of TAP block and acetaminophen and NSAID provided less variability in dynamic pain compared with either treatment alone.
机构:
Univ Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, FranceUniv Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, France
Bonnet, F.
;
Berger, J.
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Univ Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, FranceUniv Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, France
Berger, J.
;
Aveline, C.
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机构:
Polyclin Sevigne, Cesson Sevigne, FranceUniv Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, France
机构:
Univ Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA
Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USAUniv Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA
Dworkin, Robert H.
;
McDermott, Michael P.
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机构:
Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA
Univ Rochester, Sch Med & Dent, Dept Biostat, Rochester, NY 14642 USA
Univ Rochester, Sch Med & Dent, Dept Computat Biol, Rochester, NY 14642 USAUniv Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA
McDermott, Michael P.
;
Raja, Srinivasa N.
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Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD USAUniv Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA
机构:
Univ Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, FranceUniv Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, France
Bonnet, F.
;
Berger, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, FranceUniv Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, France
Berger, J.
;
Aveline, C.
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h-index: 0
机构:
Polyclin Sevigne, Cesson Sevigne, FranceUniv Paris 06, Tenon Hosp, AP HP, Dept Anaesthet & Intens Care Med, F-75020 Paris, France
机构:
Univ Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA
Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USAUniv Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA
Dworkin, Robert H.
;
McDermott, Michael P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA
Univ Rochester, Sch Med & Dent, Dept Biostat, Rochester, NY 14642 USA
Univ Rochester, Sch Med & Dent, Dept Computat Biol, Rochester, NY 14642 USAUniv Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA
McDermott, Michael P.
;
Raja, Srinivasa N.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD USAUniv Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14627 USA