The Current Status of Immunotherapies in Esophagogastric Cancer

被引：12

作者：

Ku, Geoffrey Y. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv, 300 East 66th St,Room 1035, New York, NY 10065 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 02期

关键词：

Adenocarcinoma; Squamous cell carcinoma; Gastric; Esophageal; Immunotherapy; Immune checkpoint; PD-1; PD-L1; IPILIMUMAB; MELANOMA; PEMBROLIZUMAB; MONOTHERAPY; NIVOLUMAB; BLOCKADE; TRIAL;

D O I：

10.1016/j.hoc.2018.12.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review summarizes completed and ongoing studies evaluating the activity of immune checkpoint inhibitors in esophagogastric cancer.

引用

页码：323 / +

页数：17

共 39 条

[11] Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation [J].

Freeman, GJ ;

Long, AJ ;

Iwai, Y ;

Bourque, K ;

Chernova, T ;

Nishimura, H ;

Fitz, LJ ;

Malenkovich, N ;

Okazaki, T ;

Byrne, MC ;

Horton, HF ;

Fouser, L ;

Carter, L ;

Ling, V ;

Bowman, MR ;

Carreno, BM ;

Collins, M ;

Wood, CR ;

Honjo, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (07) :1027-1034

[12] Preliminary safety data from KEYNOTE-059: Pembrolizumab plus 5-fluorouracil (5-FU) and cisplatin for first-line treatment of advanced gastric cancer [J].

Fuchs, Charles S. ;

Ohtsu, Atsushi ;

Tabernero, Josep ;

Van Cutsem, Eric ;

Wang, Jiang Dian ;

Lam, Baohoang ;

Dalal, Rita ;

Koshiji, Minori ;

Bang, Yung-Jue .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)

[13] Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial [J].

Fuchs, Charles S. ;

Tomasek, Jiri ;

Yong, Cho Jae ;

Dumitru, Filip ;

Passalacqua, Rodolfo ;

Goswami, Chanchal ;

Safran, Howard ;

dos Santos, Lucas Vieira ;

Aprile, Giuseppe ;

Ferry, David R. ;

Melichar, Bohuslav ;

Tehfe, Mustapha ;

Topuzov, Eldar ;

Zalcberg, John Raymond ;

Chau, Ian ;

Campbell, William ;

Sivanandan, Choondal ;

Pikiel, Joanna ;

Koshiji, Minori ;

Hsu, Yanzhi ;

Liepa, Astra M. ;

Gao, Ling ;

Schwartz, Jonathan D. ;

Tabernero, Josep .

LANCET, 2014, 383 (9911) :31-39

[14] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma [J].

Hodi, F. Stephen ;

O'Day, Steven J. ;

McDermott, David F. ;

Weber, Robert W. ;

Sosman, Jeffrey A. ;

Haanen, John B. ;

Gonzalez, Rene ;

Robert, Caroline ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Akerley, Wallace ;

van den Eertwegh, Alfons J. M. ;

Lutzky, Jose ;

Lorigan, Paul ;

Vaubel, Julia M. ;

Linette, Gerald P. ;

Hogg, David ;

Ottensmeier, Christian H. ;

Lebbe, Celeste ;

Peschel, Christian ;

Quirt, Ian ;

Clark, Joseph I. ;

Wolchok, Jedd D. ;

Weber, Jeffrey S. ;

Tian, Jason ;

Yellin, Michael J. ;

Nichol, Geoffrey M. ;

Hoos, Axel ;

Urba, Walter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) :711-723

Horvat, Troy Z. ;

Adel, Nelly G. ;

Thu-Oanh Dung ;

Momtaz, Parisa ;

Postow, Michael A. ;

Callahan, Margaret K. ;

Carvajal, Richard D. ;

Dickson, Mark A. ;

D'Angelo, Sandra P. ;

Woo, Kaitlin M. ;

Panageas, Katherine S. ;

Wolchok, Jedd D. ;

Chapman, Paul B. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (28) :3193-+

[16] Lapatinib in Gastric Cancer: What Is the LOGiCal Next Step? [J].

Janjigian, Yelena Y. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (05) :401-+

[17] Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer. [J].

Kantoff, Philip W. ;

Higano, Celestia S. ;

Shore, Neal D. ;

Berger, E. Roy ;

Small, Eric J. ;

Penson, David F. ;

Redfern, Charles H. ;

Ferrari, Anna C. ;

Dreicer, Robert ;

Sims, Robert B. ;

Xu, Yi ;

Frohlich, Mark W. ;

Schellhammer, Paul F. ;

Ahmed, T. ;

Amin, A. ;

Arseneau, J. ;

Barth, N. ;

Bernstein, G. ;

Bracken, B. ;

Burch, P. ;

Caggiano, V. ;

Chin, J. ;

Chodak, G. ;

Chu, F. ;

Corman, J. ;

Curti, B. ;

Dawson, N. ;

Deeken, J. F. ;

Dubernet, T. ;

Fishman, M. ;

Flanigan, R. ;

Gailani, F. ;

Garbo, L. ;

Gardner, T. ;

Gelmann, E. ;

George, D. ;

Godfrey, T. ;

Gomella, L. ;

Guerra, M. ;

Hall, S. ;

Hanson, J. ;

Israeli, R. ;

Jancis, E. ;

Jewett, M. A. S. ;

Kassabian, V. ;

Katz, J. ;

Klotz, L. ;

Koeneman, K. ;

Koh, H. ;

Kratzke, R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (05) :411-422

[18] Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity [J].

Karbach, Julia ;

Neumann, Antje ;

Brand, Kathrin ;

Wahle, Claudia ;

Siegel, Ekkehard ;

Maeurer, Markus ;

Ritter, Erika ;

Tsuji, Takamasa ;

Gnjatic, Sacha ;

Old, Lloyd J. ;

Ritter, Gerd ;

Jaeger, Elke .

CLINICAL CANCER RESEARCH, 2012, 18 (19) :5449-5459

[19] CD28 AND CTLA-4 HAVE OPPOSING EFFECTS ON THE RESPONSE OF T-CELLS TO STIMULATION [J].

KRUMMEL, MF ;

ALLISON, JP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (02) :459-465

[20] Management of gastric cancer [J].

Ku, Geoffrey Y. ;

Ilson, David H. .

CURRENT OPINION IN GASTROENTEROLOGY, 2014, 30 (06) :596-602

← 1 2 3 4 →