Hepatic stem cell niches

被引：121

作者：

Kordes, Claus ^{[1
]}

Haeussinger, Dieter ^{[1
]}

机构：

[1] Univ Dusseldorf, Clin Gastroenterol Hepatol & Infect Dis, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 05期

关键词：

PERIVASCULAR NERVE-STIMULATION; MEDIATED LIVER-REGENERATION; HEPATOCYTE GROWTH-FACTOR; WNT SIGNALING MAINTAINS; DUCT-LIKE CELLS; STELLATE CELLS; RAT-LIVER; OVAL CELLS; PROGENITOR CELLS; BONE-MARROW;

D O I：

10.1172/JCI66027

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stem cell niches are special microenvironments that maintain stem cells and control their behavior to ensure tissue homeostasis and regeneration throughout life. The liver has a high regenerative capacity that involves stem/progenitor cells when the proliferation of hepatocytes is impaired. In recent years progress has been made in the identification of potential hepatic stem cell niches. There is evidence that hepatic progenitor cells can originate from niches in the canals of Hering; in addition, the space of Disse may also serve as a stem cell niche during fetal hematopoiesis and constitute a niche for stellate cells in adults.

引用

页码：1874 / 1880

页数：7

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