Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin

被引：43

作者：

He, Zhongmei ^{[1
,3
]}

Tian, Yudan ^{[2
]}

Zhang, Xiantao ^{[3
]}

Bing, Bai ^{[3
]}

Zhang, Lianxue ^{[1
]}

Wang, Huaisheng ^{[4
]}

Zhao, Wenjie ^{[4
]}

机构：

[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130116, Peoples R China

[2] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China

[3] Xiuzheng Pharmaceut Grp Co Ltd, Changchun 130012, Peoples R China

[4] Jilin Tianyao Sci & Technol Co Ltd, Changchun 130012, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2012年 / 26卷 / 23期

基金：

中国国家自然科学基金;

关键词：

diosgenin; saponin; immunomodulation; anti-tumour activity;

D O I：

10.1080/14786419.2011.648192

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Diosgenin is a naturally occurring steroidal saponin abundantly present in many medical plants. In this study, diosgenin could significantly inhibit the growth of sarcoma-180 tumour cells in vivo, and remarkably increase thymus and spleen weights of S-180-bearing mice and upgrade the secretion level of TNF-alpha in serum. Moreover, diosgenin could stimulate lymphocyte transformation and enhance phagocytic capability of macrophages in vitro, and remarkably promoted the secretion of NO and TNF-alpha in macrophages. These results suggested that diosgenin could improve both specific and non-specific cellular immune responses, and the anti-tumour effects of diosgenin were achieved by immunostimulating properties instead of direct cytotoxicity.

引用

页码：2243 / 2246

页数：4