Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial fibrillation

Background: Cardioversion (CV) success of atrial fibrillation (AF) inversely correlates to the size of the left atrium (LA). Atrial fibrillation and its most important risk factor, congestive heart failure (CHF), both induce atrial structural enlargement and fibrosis. To investigate the effect of AF and CHF on atrial dilatation and fibrosis, and to estimate whether echocardiographically determined atrial size may be used as a marker for atrial fibrosis. Methods: In six dogs, pacemakers were implanted followed by HIS bundle ablation. After 4 weeks of rapid ventricular stimulation (185 bpm) for CHF induction, additional rapid atrial stimulation (500 bpm) was maintained for 7 weeks to induce AF. Serial determinations of echocardiographic atrial size were performed. Seven dogs with sinus rhythm served as histological controls. Postmortem tissue was obtained to determine the degree and composition of atrial fibrosis. Results: While the ejection fraction of the AF/CHF dogs decreased significantly from 57 +/- 5% to 19 +/- 7% (P<01), an increased degree of atria] fibrosis was found (right atrium [RA], 4.9 +/- 2.0% to 19.9 +/- 5.4%; LA, 4.4 +/- 1.6% to 22.2 +/- 3.2%; P<.01), accompanied by a significant increase of atrial volumes (LA: 21 +/- 4 to 44 +/- 4 mm(3); P<.01; RA: 10 +/- 3 to 18 +/- 6 mm(3); P<.05) and LA diameters (34 4 to 43 2 turn, P<.05). Atrial fibrosis and size significantly correlated. Conclusions: Atrial fibrillation/CHF leads to p significant atrial fibrosis and dilation. The increased echocardiographic size correlates to the degree of atrial fibrosis and may be used as clinical marker for atrial fibrosis. The fibrosis accompanying atrial dilatation may also explain why LA size, as determined by echocardiography, is a strong predictor of CV success. (C) 2008 Elsevier Inc. All rights reserved.