Effect of microwave irradiation on the synthesis of 1,2,4-triazol-3-one derivatives and their antimicrobial activities

被引：17

作者：

Kahveci, Bahittin ^{[1
]}

Yilmaz, Fatih ^{[2
]}

Mentese, Emre ^{[2
]}

Beris, Fatih Saban ^{[3
]}

机构：

[1] Karadeniz Tech Univ, Fac Hlth Sci, TR-61080 Trabzon, Turkey

[2] Recep Tayyip Erdogan Univ, Dept Chem, Art & Sci Fac, TR-53100 Rize, Turkey

[3] Recep Tayyip Erdogan Univ, Dept Biol, Art & Sci Fac, TR-53100 Rize, Turkey

来源：

JOURNAL OF CHEMICAL RESEARCH | 2012年 / 08期

关键词：

microwave irradiation; triazoles; 3,5-dichloroaniline; 1,3,4-oxadiazole; antimicrobial activity;

D O I：

10.3184/174751912X13400138806685

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An easy efficient method for the synthesis of N-(3,5-dichlorophenyl)-5-alkyl/aryl-3H-1,2,4-triazol-3-one derivatives under microwave irradiation has been developed using the reaction of 3,5-dichloroaniline and ethoxycarbonylhydrazones. This reaction occurs more efficiently and faster than the conventional heating method. We obtained 5-mercapto-1,3,4-oxadiazol derivatives by this method. The newly synthesised compounds have been tested for their antimicrobial activity against Enterobacter cloaceae, Escherichia coli, Klebsiella pneumonie, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella typhimurium, Yersinia pseudotuberculosis, Bacillus subtilis and Staphylococcus aereus.

引用

页码：484 / 488

页数：5

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