Evidence-based Toxicology for the 21st Century: Opportunities and Challenges

被引：35

作者：

Stephens, Martin L. ^{[1
]}

Andersen, Melvin ^{[2
]}

Becker, Richard A. ^{[3
]}

Betts, Kellyn

Boekelheide, Kim ^{[4
]}

Carney, Ed ^{[5
]}

Chapin, Robert ^{[6
]}

Devlin, Dennis ^{[7
]}

Fitzpatrick, Suzanne ^{[8
]}

Fowle, John R., III ^{[9
]}

Harlow, Patricia ^{[10
]}

Hartung, Thomas ^{[1
]}

Hoffmann, Sebastian ^{[11
]}

Holsapple, Michael ^{[12
]}

Jacobs, Abigail ^{[10
]}

Judson, Richard ^{[13
]}

Naidenko, Olga ^{[14
]}

Pastoor, Tim ^{[15
]}

Patlewicz, Grace ^{[16
]}

Rowan, Andrew ^{[17
]}

Scherer, Roberta ^{[1
]}

Shaikh, Rashid ^{[18
]}

Simon, Ted ^{[19
]}

Wolf, Douglas ^{[13
]}

Zurlo, Joanne ^{[1
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD USA

[2] Hamner Inst Hlth Sci, Res Triangle Pk, NC USA

[3] Amer Chem Council, Washington, DC USA

[4] Brown Univ, Providence, RI 02912 USA

[5] Dow Chem, Midland, MI USA

[6] Pfizer Global R&D, Groton, CT USA

[7] ExxonMobil, Irving, TX USA

[8] US FDA, College Pk, MD USA

[9] US EPA, Pittsboro, NC USA

[10] US FDA, Silver Spring, MD USA

[11] Seh Consulting Serv, Paderborn, Germany

[12] Battelle Mem Inst, Columbus, OH USA

[13] US EPA, Res Triangle Pk, NC 27711 USA

[14] Environm Working Grp, Washington, DC USA

[15] Syngenta, Greensboro, NC USA

[16] DuPont Haskell Global Ctr Hlth & Environm Sci, Newark, DE USA

[17] Humane Soc Int, Gaithersburg, MD USA

[18] Hlth Effects Inst, Boston, MA USA

[19] Ted Simon LLC, Winston, GA USA

来源：

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION | 2013年 / 30卷 / 01期

关键词：

evidence-based toxicology; evidence-based medicine; systematic review; validation; test method assessment; EVIDENCE-BASED MEDICINE; URINARY BIOMARKERS; ARSENIC EXPOSURE; TOXICITY; QUALIFICATION; VALIDATION; FRAMEWORK; INJURY;

D O I：

10.14573/altex.2013.1.074

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on "Evidence-based Toxicology for the 21st Century: Opportunities and Challenges" in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathway-based testing methods consistent with the 2007 National Research Council report on "Toxicity Testing in the 21st Century" as well as to adopt a governance structure and work processes to move that effort forward. The workshop served to clarify evidence-based approaches and to provide food for thought on substantive and administrative activities for the EBTC. Priority activities include conducting pilot studies to demonstrate the value of evidence-based approaches to toxicology, as well as conducting educational outreach on these approaches.

引用

页码：74 / 103

页数：30

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