Mechanisms and Control of Impurities in Continuous Crystallization: A Review

被引：47

作者：

Darmali, Christine ^{[1
]}

Mansouri, Shahnaz ^{[1
]}

Yazdanpanah, Nima ^{[2
]}

Woo, Meng W. ^{[1
]}

机构：

[1] Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2019年 / 58卷 / 04期

关键词：

CONTINUOUS PREFERENTIAL CRYSTALLIZATION; CONTINUOUS MIXED-SUSPENSION; RESIDENCE TIME DISTRIBUTION; CRYSTAL SIZE DISTRIBUTION; PLUG-FLOW CRYSTALLIZER; FLUIDIZED-BED; MSMPR CRYSTALLIZATION; SECONDARY NUCLEATION; STIRRED-TANK; ANTISOLVENT CRYSTALLIZATION;

D O I：

10.1021/acs.iecr.8b04560

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Crystallization has been applied to a broad range of industries such as bulk and fine chemicals and the pharmaceutical and food industries. It is important to strategically control the in situ purification process during crystallization to meet the regulatory and functional specifications of the crystals. While the control of the crystallization purification process has been widely discussed for batch crystallizers, there has been little focus with the literature on controlling purification for continuous crystallizers. Continuous crystallization is a more intensified approach to crystallization, with lower capital footprint and potentially offering more consistent quality control. This review paper provides an in-depth discussion of the strategies and scientific understanding in controlling the crystallization purification process in continuous crystallization. In particular, it describes how scientific understanding in the purification process, generated so far for batch crystallization, can be translated to continuous crystallization.

引用

页码：1463 / 1479

页数：17

共 173 条

[21] Characterization and modelling of antisolvent crystallization of salicylic acid in a continuous oscillatory baffled crystallizer [J].