Dietary polyphenols for atherosclerosis: A comprehensive review and future perspectives

被引：55

作者：

Bahramsoltani, Roodabeh ^{[1
,2
]}

Ebrahimi, Farnaz ^{[3
]}

Farzaei, Mohammad Hosein ^{[4
,5
]}

Baratpourmoghaddam, Armaghan ^{[3
]}

Ahmadi, Pardis ^{[3
]}

Rostamiasrabadi, Pourouchista ^{[6
]}

Amirabadi, Amir Hossein Rasouli ^{[3
]}

Rahimi, Roja ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Sch Tradit Med, Dept Tradit Pharm, Tehran 1417653761, Iran

[2] USERN, PhytoPharmacol Interest Grp PPIG, Tehran, Iran

[3] Isfahan Univ Med Sci, Sch Pharm, Pharm Students Res Comm, Esfahan, Iran

[4] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran

[5] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran

[6] Univ Tehran, Dept Chem, Fac Sci, Tehran, Iran

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2019年 / 59卷 / 01期

关键词：

Dietary Supplements; atherosclerosis; phytochemical; lipid profile; blood pressure; adhesion molecule; RANDOMIZED DOUBLE-BLIND; GREEN TEA CATECHINS; OLIVE OIL POLYPHENOLS; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; CARDIOVASCULAR-DISEASE; ANTIOXIDANT PROPERTIES; POSTMENOPAUSAL WOMEN; REGULAR CONSUMPTION; PRIMARY PREVENTION;

D O I：

10.1080/10408398.2017.1360244

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Atherosclerosis is one of the most prevalent reasons for premature death in adults. Despite the several conventional drugs in the market; many patients are not completely treated. Here we comprehensively review current clinical evidence regarding the efficacy of dietary polyphenols in atherosclerosis and related complications. PubMed, Cochrane library and Scopus were searched from inception until August 2016 to obtain clinical trials in which polyphenols were evaluated in cardiovascular parameters related to atherosclerosis. From total of 13031 results, 49 clinical trials were finally included. Tyrosol derivatives from virgin olive oil, catechins and theaflavins from green and black tea, cocoa polyphenols, and red grape resveratrol, as well as anthocyanins were the most studied polyphenolic compounds which could regulate lipid profile, inflammation and oxidative stress, blood pressure, endothelial function, and cell adhesion molecules. The most important limitations of the included trials were small sample size, short follow up, and unqualified methodology. Future well-designed clinical trials are necessary to provide better level of evidence for clinical decision making.

引用

页码：114 / 132

页数：19

共 112 条

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