New Structure Descriptor in the Structure-Activity Relationship Study on the Suppression of Aryl Hydrocarbon Receptor Transformation by Anthraquinones

被引：0

作者：

Kawase, Masaya ^{[1
]}

Saito, Tadashi ^{[2
]}

Yasunaga, Teruo ^{[3
]}

Takagi, Tatsuya ^{[4
]}

Fukuda, Itsuko ^{[5
]}

Ashida, Hitoshi ^{[5
]}

机构：

[1] Nagahama Inst Biosci & Technol, Fac Biosci, Nagahama 5260829, Japan

[2] Osaka Univ, Radioisotope Res Ctr, Toyonaka, Osaka 5600042, Japan

[3] Osaka Univ, Genome Informat Res Ctr, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[5] Kobe Univ, Grad Sch Agr Sci, Kobe, Hyogo 6578501, Japan

来源：

FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2012年 / 18卷 / 02期

关键词：

QSAR; new descriptor; anthraquinones; aryl hydrocarbon receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; hepatocytes; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; QSAR;

D O I：

10.3136/fstr.18.173

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A new descriptor showing the positions of functional groups in compounds with the same main backbone was developed. This descriptor was applied to the Quantitative Structure-Activity Relationship (QSAR) study on the suppression activities of anthraquinones via transformation of the aryl hydrogen receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin. It was shown that the newly developed descriptor played an important role in the QSAR study.

引用

页码：173 / 176

页数：4

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