Molecular links between obesity and breast cancer

被引：331

作者：

Lorincz, A. M.

Sukumar, S.

机构：

[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Breast Canc Program, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Grad Program Pathobiol, Baltimore, MD 21231 USA

来源：

ENDOCRINE-RELATED CANCER | 2006年 / 13卷 / 02期

关键词：

D O I：

10.1677/erc.1.00729

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer continues to be a major health problem for women in the USA and worldwide. There is a need to identify and take steps to alter modifiable breast cancer risks. Conditions of obesity and overweight are risk factors that have reached epidemic proportions. This article reviews the evidence in the literature that test mechanism-based hypotheses which attempt to provide a molecular basis for a causal link between obesity and breast cancer risk, particularly the effects of metabolic syndrome and insulin resistance, peripheral estrogen aromatization in adipose tissue, and direct effect of adipokines. Future areas for study and implications for therapy are discussed.

引用

收藏

页码：279 / 292

页数：14

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