The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus

被引：20
作者：
Prasad, Abhishek N. [1 ]
Brackney, Doug. E. [1 ]
Ebel, Gregory D. [1 ]
机构：
[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA
来源：
VIRUSES-BASEL | 2013年 / 5卷 / 12期
基金：
美国国家卫生研究院;
关键词：
West Nile virus; innate immunity; RNAi; Toll; Imd; Jak/STAT; autophagy; apoptosis; arbovirus; mosquito; SEMLIKI-FOREST-VIRUS; ENDOPLASMIC-RETICULUM STRESS; QUANTITATIVE TRAIT LOCI; DOUBLE-STRANDED-RNA; ANTIVIRAL IMMUNITY; HOST-DEFENSE; CULEX-PIPIENS; DENGUE VIRUS; GENETIC INTERFERENCE; PATHOLOGICAL-CHANGES;
D O I：
10.3390/v5123142
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.
引用
收藏
页码：3142 / 3170
页数：29
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