Preproenkephalin, is a Th2 cytokine but is not required for Th2 differentiation in vitro

被引：22
作者：
Hook, S
Camberis, M
Prout, M
Konig, M
Zimmer, A
Van Heeke, G
Le Gros, G
机构：
[1] Wellington Sch Med, Malaghan Inst Med Res, Wellington, New Zealand
[2] NIMH, Genet Lab, Unit Mouse Genet, Bethesda, MD 20892 USA
[3] Novartis Horsham Res Ctr, Horsham, W Sussex, England
来源：
IMMUNOLOGY AND CELL BIOLOGY | 1999年 / 77卷 / 05期
基金：
英国惠康基金;
关键词：
IL-4; preproenkephalin; Th2 immune responses;
D O I：
10.1046/j.1440-1711.1999.00842.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Preproenkephalin (PPNK) mRNA expression has been detected in many cells of the immune system, including monocytes and lymphocytes. In the present paper. the expression of PPNK mRNA in purified CD4(+) Th1 and Th2 lymphocyte subpopulations is investigated and correlated with the presence of the opioid neuropeptides leu- and met-enkephalin. We found that PPNK mRNA and met-enkephalin were present at higher levels in the Th2 cultures compared with the Th1 cultures. Lymphocytes from PPNK-deficient mice were then used to look at the role of PPNK in Th2 lymphocyte differentiation. Lymphocytes from these mice could be driven into a Th2 phenotype, suggesting that cultures containing IL-4 do not require PPNK for Th2 differentiation.
引用
收藏
页码：385 / 390
页数：6
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