New alleles and mutational events at 14 STR loci from different German populations

被引：20

作者：

Becker, Dorit ^{[1
]}

Bender, Klaus ^{[2
]}

Edelmann, Jeanett ^{[3
]}

Goetz, Frank ^{[4
]}

Henke, Lotte ^{[5
]}

Hering, Sandra ^{[6
]}

Hohoff, Carsten ^{[7
]}

Hoppe, Karolin ^{[7
]}

Klintschar, Michael ^{[8
]}

Muche, Matthias ^{[9
]}

Rolf, Burkhard ^{[10
]}

Szibor, Reinhard ^{[11
]}

Weirich, Volker ^{[12
]}

Jung, Martin ^{[1
]}

Brabetz, Werner ^{[1
]}

机构：

[1] Biotype AG, D-01109 Dresden, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Legal Med, D-55131 Mainz, Germany

[3] Univ Leipzig, Inst Legal Med, D-04103 Leipzig, Germany

[4] Qualitype AG, D-01109 Dresden, Germany

[5] Inst Blutgruppenforsch LGC GmbH, D-50672 Cologne, Germany

[6] Univ Dresden, Inst Legal Med, D-01307 Dresden, Germany

[7] Univ Munster, Inst Legal Med, D-48149 Munster, Germany

[8] Univ Halle Wittenberg, Inst Legal Med, D-06112 Halle, Germany

[9] Inst Blood Grp Serol & Genet, D-22081 Hamburg, Germany

[10] Univ Munich, Inst Legal Med, D-80337 Munich, Germany

[11] Univ Magdeburg, Inst Legal Med, D-39120 Magdeburg, Germany

[12] Univ Rostock, Inst Legal Med, D-18055 Rostock, Germany

来源：

FORENSIC SCIENCE INTERNATIONAL-GENETICS | 2007年 / 1卷 / 3-4期

关键词：

DNA typing; Short tandem repeat; Primer binding site mutation; Silent allele; Mutation rate;

D O I：

10.1016/j.fsigen.2007.04.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The molecular origin of DNA mutations and the mutation rates were analyzed at 14 short tandem repeat (STR) loci with samples from trio cases derived from 10 different German Population samples. STIR loci comprised of D2S1360, D3S1744, D4S2366, D5S2500, D6S474, D7S1517, D8S1132, D10S2325, D12S391, D18S51, D19S246, D20S480, D21S226, and D22S689. In a total of 488 meioses, 16 isolated,genetic inconsistencies in 8 different STRs were observed, whereas no mutations were found at the other loci. The data of five mutations suggested the presence of silent or null alleles due to sequence variation in primer binding site. This Could be confirmed for four suspected cases by the use of alternative printer sets and by DNA sequence analyses. Furthermore, this study revealed nine new allelic variants at five different loci. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：232 / 237

页数：6

共 27 条

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