A peptide antibiotic from human skin

被引：1114

作者：

Harder, J

Bartels, J

Christophers, E

Schroder, JM

机构：

[1] University of Kiel,Department of Dermatology

来源：

NATURE | 1997年 / 387卷 / 6636期

关键词：

D O I：

10.1038/43088

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To avoid opportunistic infections, plants and animals have developed antimicrobial peptides in their epithelia that can form pores in the cytoplasmic membrane of microorganisms1. After contact with microorganisms, vertebrate skin2, trachea and tongue epithelia3 are rich sources of peptide antibiotics1, which may explain the unexpected resistance of these tissues to infection. Here we report that human skin is protected in a similar way by an inducible, transcriptionally regulated, antibiotic peptide, which resembles those in other mammals.

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页码：861 / 861

页数：1

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