Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway

被引：30

作者：

Son, Tae Gen ^{[1
]}

Kawamoto, Elisa M. ^{[1
]}

Yu, Qian-Sheng ^{[1
]}

Greig, Nigel H. ^{[1
]}

Mattson, Mark P. ^{[1
,2
]}

Camandola, Simonetta ^{[1
]}

机构：

[1] NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 433卷 / 04期

关键词：

Nrf2; Glutamate; Naphthazarin; Antioxidant response element; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASE; NEUROPROTECTION; ASTROCYTES; PHYTOCHEMICALS; MECHANISMS; CELLS;

D O I：

10.1016/j.bbrc.2013.03.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cellular stress response pathway involved in neuroprotection. We previously screened several natural phytochemicals and identified plumbagin as a novel activator of the Nrf2/ARE pathway that can protect neurons against ischemic injury. Here we extended our studies to natural and synthetic derivatives of plumbagin. We found that 5,8-dimethoxy-1,4-naphthoquinone (naphthazarin) is a potent activator of the Nrf2/ARE pathway, up-regulates the expression of Nrf2-driven genes in primary neuronal and glial cultures, and protects neurons against glutamate-induced excitotoxicity. Published by Elsevier Inc.

引用

页码：602 / 606

页数：5

共 21 条

[1] Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury [J].

Barreto, George E. ;

Gonzalez, Janneth ;

Torres, Yolima ;

Morales, L. .

NEUROSCIENCE RESEARCH, 2011, 71 (02) :107-113

[2]

Calkins MJ, 2009, ANTIOXID REDOX SIGN, V11, P497, DOI 10.1089/ARS.2008.2242

[3] OXIDATIVE STRESS, GLUTAMATE, AND NEURODEGENERATIVE DISORDERS [J].

COYLE, JT ;

PUTTFARCKEN, P .

SCIENCE, 1993, 262 (5134) :689-695

[4] Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals [J].

Gupta, Subash C. ;

Kim, Ji Hye ;

Prasad, Sahdeo ;

Aggarwal, Bharat B. .

CANCER AND METASTASIS REVIEWS, 2010, 29 (03) :405-434

[5] The Nrf2-ARE Pathway An Indicator and Modulator of Oxidative Stress in Neurodegeneration [J].

Johnson, Jeffrey A. ;

Johnson, Delinda A. ;

Kraft, Andrew D. ;

Calkins, Marcus J. ;

Jakel, Rebekah J. ;

Vargas, Marcelo R. ;

Chen, Pei-Chun .

MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS, 2008, 1147 :61-69

[6]

Keller JN, 1996, J NEUROCHEM, V67, P2300

[7] Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease [J].

Kim, Sa Suk ;

Lim, Juhee ;

Bang, Yeojin ;

Gal, Jiyeong ;

Lee, Sang-Uk ;

Cho, Young-Chang ;

Yoon, Goo ;

Kang, Bok Yun ;

Cheon, Seung Hoon ;

Choi, Hyun Jin .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2012, 23 (10) :1314-1323

[8] Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult [J].

Kraft, AD ;

Johnson, DA ;

Johnson, JA .

JOURNAL OF NEUROSCIENCE, 2004, 24 (05) :1101-1112

[9] Glutamate receptors, neurotoxicity and neurodegeneration [J].

Lau, Anthony ;

Tymianski, Michael .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2010, 460 (02) :525-542

[10] NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons [J].

Lee, JM ;

Shih, AY ;

Murphy, TH ;

Johnson, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) :37948-37956

← 1 2 3 →