Effect of curcumin on the expression of LDL receptor in mouse macrophages

被引：32

作者：

Fan, CL ^{[1
]}

Wo, XD ^{[1
]}

Qian, Y ^{[1
]}

Yin, J ^{[1
]}

Gao, LP ^{[1
]}

机构：

[1] Zhejiang Coll Trad Chinese Med, Inst Mol Med, Hangzhou 310053, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 105卷 / 1-2期

关键词：

curcumin; low density lipoprotein receptor; gene expression; macrophage;

D O I：

10.1016/j.jep.2005.11.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

To investigate the molecular mechanisms of lipid-lowering drug, Rhizoma Curcumae Longae, we treated the mouse macrophages with curcumin, which was purified from the ethanol extraction of Rhizoma Curcumae Longae. The LDL receptors expressed in the macrophages were determined by ELISA, FLISA and assay of LDL uptake. Here for the first time, we found that curcumin obviously up-regulated the expression of LDL receptor in mouse macrophages, and the dose-effect relationship was demonstrated. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：251 / 254

页数：4