π-Acid Mediated Insertion of Alkynes into Carbon-Heteroatom σ-Bonds

被引：38

作者：

Adcock, Holly V. ^{[1
]}

Davies, Paul W. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

catalysis; gold; platinum; alkynes; nucleophilic addition; cyclisation; heterocycles; PALLADIUM-CATALYZED CYCLIZATION; HOMOGENEOUS GOLD CATALYSIS; C-N BOND; INTRAMOLECULAR CARBOALKOXYLATION; GOLD(I)-CATALYZED CYCLOISOMERIZATION; 2,3-DISUBSTITUTED BENZOFURANS; HOMOPROPARGYLIC AMINES; EFFICIENT SYNTHESIS; ATOM ECONOMY; PLATINUM;

D O I：

10.1055/s-0032-1316788

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rapidly expanding field of gold and platinum pi-acid catalysis has led to the discovery of diverse transformations that are initiated with nucleophilic attack onto a metal-activated alkyne. This review brings together those reactions which employ a hetero-atom nucleophile bearing a functional group that can subsequently migrate to effect a formal insertion of the alkyne into a carbon-heteroatom sigma-bond. This reactivity profile is encountered in a range of efficient and powerful cycloisomerisations for the preparation of carbo-and heterocycles.

引用

页码：3401 / 3420

页数：20

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