C5-Regioselective C-H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

被引：34

作者：

Zhang, Yingchao ^{[1
]}

Wen, Chunxia ^{[1
]}

Li, Jizhen ^{[1
]}

机构：

[1] Jilin Univ, Dept Organ Chem, Coll Chem, Jiefang Rd 2519, Changchun 130023, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 11期

基金：

中国国家自然科学基金;

关键词：

BOND-FORMING REACTIONS; N-FLUOROBENZENESULFONIMIDE; MILD CONDITIONS; REGIOSELECTIVE C; AROMATIC AMIDES; SODIUM-HALIDES; ASSISTED FLUORINATION; COPPER; QUINOLINES; HALOGENATION;

D O I：

10.1039/c7ob03059b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient regioselective C-H fluorination of 8-aminoquinoline amides and sulfonamides at the C5 position was achieved. Using Selectfluor as a F reagent and HOAc as an additive, the reaction proceeds smoothly via a radical pathway. This method features metal-free conditions, a broad substrate scope and operational simplicity.

引用

页码：1912 / 1920

页数：9

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