Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T2 contrast agent with tunable proton relaxivities

被引：100

作者：

Ye, Fei ^{[1
]}

Laurent, Sophie ^{[2
]}

Fornara, Andrea ^{[1
,3
]}

Astolfi, Laura ^{[4
]}

Qin, Jian ^{[1
,5
]}

Roch, Alain ^{[2
]}

Martini, Alessandro ^{[4
]}

Toprak, Muhammet S. ^{[1
]}

Muller, Robert N. ^{[2
]}

Muhammed, Mamoun ^{[1
]}

机构：

[1] Royal Inst Technol KTH, Funct Mat Div, S-16440 Stockholm, Sweden

[2] Univ Mons, Dept Gen Organ & Biomed Chem, NMR & Mol Imaging Lab, B-7000 Mons, Belgium

[3] Inst Surface Chem, YKI, S-11428 Stockholm, Sweden

[4] Univ Padua, Bioacoust Res Lab, Dept Neurosci, I-35129 Padua, Italy

[5] ABB Corp Res, S-72178 Vasteras, Sweden

来源：

CONTRAST MEDIA & MOLECULAR IMAGING | 2012年 / 7卷 / 05期

关键词：

MRI; contrast agent; superparamagnetic; iron oxide; mesoporous silica; coating thickness; tunable relaxivity; biocompatibility; MAGNETIC-RESONANCE; GOLD NANORODS; SIZE; NANOCRYSTALS; RELAXOMETRY; RELAXATION; DESIGN; CELLS; WATER;

D O I：

10.1002/cmmi.1473

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Monodisperse mesoporous silica (mSiO2) coated superparamagnetic iron oxide (Fe3O4@mSiO2) nanoparticles (NPs) have been developed as a potential magnetic resonance imaging (MRI) T2 contrast agent. To evaluate the effect of surface coating on MRI contrast efficiency, we examined the proton relaxivities of Fe3O4@mSiO2 NPs with different coating thicknesses. It was found that the mSiO2 coating has a significant impact on the efficiency of Fe3O4 NPs for MRI contrast enhancement. The efficiency increases with the thickness of mSiO2 coating and is much higher than that of the commercial contrast agents. Nuclear magnetic resonance (NMR) relaxometry of Fe3O4@mSiO2 further revealed that mSiO2 coating is partially permeable to water molecules and therefore induces the decrease of longitudinal relaxivity, r1. Biocompatibility evaluation of various sized (ca. 3595 nm) Fe3O4@mSiO2 NPs was tested on OC-k3 cells and the result showed that these particles have no negative impact on cell viability. The enhanced MRI efficiency of Fe3O4@mSiO2 highlights these coreshell particles as highly efficient T2 contrast agents with high biocompatibility. Copyright (C) 2012 John Wiley & Sons, Ltd.

引用

页码：460 / 468

页数：9

共 51 条

[1] Contrast-enhanced blood-pool MR angiography with optimized iron oxides: Effect of size and dose on vascular contrast enhancement in rabbits [J].

Allkemper, T ;

Bremer, C ;

Matuszewski, L ;

Ebert, W ;

Reimer, P .

RADIOLOGY, 2002, 223 (02) :432-438

[2]

Astolfi L., 2008, AUDIOL MED, V6, P225, DOI [10.1080/16513860802527930, DOI 10.1080/16513860802527930]

[3]

Bean C., 1959, J. Appl. Phys, V30, pS120, DOI [DOI 10.1063/1.2185850, 10.1063/1.2185850]

[4] Magnetic Resonance Imaging Contrast Agents Based on Iron Oxide Superparamagnetic Ferrofluids [J].

Casula, Maria F. ;

Floris, Patrizia ;

Innocenti, Claudia ;

Lascialfari, Alessandro ;

Marinone, Massimo ;

Corti, Maurizio ;

Sperling, Ralph A. ;

Parak, Wolfgang J. ;

Sangregorio, Claudio .

CHEMISTRY OF MATERIALS, 2010, 22 (05) :1739-1748

[5] FERROMAGNETIC PARTICLES AS CONTRAST AGENTS FOR MAGNETIC-RESONANCE-IMAGING OF LIVER AND SPLEEN [J].

DIAS, MHM ;

LAUTERBUR, PC .

MAGNETIC RESONANCE IN MEDICINE, 1986, 3 (02) :328-330

[6]

Drummond DC, 1999, PHARMACOL REV, V51, P691

[7] Reexamining the effects of particle size and surface chemistry on the magnetic properties of iron oxide nanocrystals: New insights into spin disorder and proton relaxivity [J].

Duan, Hongwei ;

Kuang, Min ;

Wang, Xiaoxia ;

Wang, Y. Andrew ;

Mao, Hui ;

Nie, Shuming .

JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (22) :8127-8131

[8]

ENGELSTAD B, 1988, MAGNETIC RESONANCE I

[9] Three-dimensionally ordered gold nanocrystal/silica superlattice thin films synthesized via sol-gel self-assembly [J].

Fan, Hongyou ;

Wright, Adam ;

Gabaldon, John ;

Rodriguez, Adrian ;

Brinker, C. Jeffrey ;

Jiang, Ying-Bing .

ADVANCED FUNCTIONAL MATERIALS, 2006, 16 (07) :891-895

[10] Polymeric/inorganic multifunctional nanoparticles for simultaneous drug delivery and visualization [J].

Fornara, Andrea ;

Recalenda, Alberto ;

Qin, Jian ;

Sugunan, Abhilash ;

Ye, Fei ;

Laurent, Sophie ;

Muller, Robert N. ;

Zou, Jing ;

Usama, Abo-Ramadan ;

Toprak, Muhammet S. ;

Muhammed, Mamoun .

MULTIFUNCTIONAL NANOPARTICLE SYSTEMS-COUPLED BEHAVIOR AND APPLICATIONS, 2010, 1257

← 1 2 3 4 5 6 →