Clinical Application of Next-generation Sequencing for the Diagnosis of Lung Squamous Cell Carcinoma: Is It Primary or Secondary?

被引：0

作者：

Aizawa, Hiroaki ^{[1
]}

Karasaki, Takahiro ^{[1
]}

Nagayama, Kazuhiro ^{[1
]}

Shinozaki-Ushiku, Aya ^{[2
]}

Aburatani, Hiroyuki ^{[3
]}

Mano, Hiroyuki ^{[4
]}

Nakajima, Jun ^{[1
]}

机构：

[1] Univ Tokyo, Dept Thorac Surg, Grad Sch Med, Tokyo, Japan

[2] Univ Tokyo, Dept Pathol, Grad Sch Med, Tokyo, Japan

[3] Univ Tokyo, Res Ctr Adv Sci & Technol, Genome Sci Div, Tokyo, Japan

[4] Natl Canc Ctr, Div Cellular Signaling, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 10期

关键词：

squamous cell carcinoma; massively parallel sequencing; next-generation sequencing; somatic mutation; INTRATUMOR HETEROGENEITY;

D O I：

10.2169/internalmedicine.3682-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An 80-year-old man with a history of cutaneous squamous cell carcinoma (SCC) was referred to our department for a solitary lung nodule. The nodule was surgically resected and diagnosed as SCC. Because the lung lesion and a previous skin lesion showed similar histological findings, the origin of the lung tumor was uncertain. Next-generation sequencing using a targeted driver oncogene panel was applied for the further examination. The lung lesion was diagnosed as primary lung SCC, as the two tumors possessed distinct somatic mutations in TP53. Recent advances in clinical sequencing have enabled us to obtain an accurate diagnosis in pathologically challenging cases.

引用

页码：1299 / 1302

页数：4

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