Hyponatremia from oxcarbazepine and carbamazepine

被引：122

作者：

Dong, XM

Leppik, IE

White, J

Rarick, J

机构：

[1] Univ Minnesota, Sch Pharm, Dept Neurol, Minneapolis, MN 55455 USA

[2] MINCEP Epilepsy Care, Minneapolis, MN USA

来源：

NEUROLOGY | 2005年 / 65卷 / 12期

关键词：

D O I：

10.1212/01.wnl.0000188819.45330.90

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies. The frequency of hyponatremia (Na+ <= 134 mEq/L) was 29.9% among OXC-treated patients and 13.5% among CBZ-treated patients (p < 0.0001). Hyponatremia (Na+ <= 128 mEq/L) was severe: 12.4% of OXC-treated patients and 2.8% of CBZ-treated patients (p < 0.001). Advanced age was a risk factor for hyponatremia. Hyponatremia, once present, persisted in both groups.

引用

收藏

页码：1976 / 1978

页数：3

相关论文

共 10 条

[1]

FRIIS ML, 1993, ACTA NEUROL SCAND, V87, P224

[2] REVIEW OF CARBAMAZEPINE-INDUCED HYPONATREMIA [J].

GANDELMAN, MS .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1994, 18 (02) :211-233

[3] CARBAMAZEPINE AND SERUM SODIUM-LEVELS [J].

KALFF, R ;

HOUTKOOPER, MA ;

MEYER, JWA ;

GOEDHART, DM ;

AUGUSTEIJN, R ;

MEINARDI, H .

EPILEPSIA, 1984, 25 (03) :390-397

[4] Hyponatremia during carbamazepine therapy in patients with intellectual disability [J].

Kelly, BD ;

Hillery, J .

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2001, 45 :152-156

[5] HYPONATREMIA DURING CARBAMAZEPINE THERAPY [J].

LAHR, MB .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 37 (06) :693-696

[6] OXCARBAZEPINE-INDUCED HYPONATREMIA, A CROSS-SECTIONAL STUDY [J].

NIELSEN, OA ;

JOHANNESSEN, AC ;

BARDRUM, B .

EPILEPSY RESEARCH, 1988, 2 (04) :269-271

[7] HYPONATREMIA AND CARBAMAZEPINE INTOXICATION [J].

OHARE, J ;

ODRISCOLL, D ;

DUGGAN, B ;

CALLAGHAN, N .

IRISH JOURNAL OF MEDICAL SCIENCE, 1980, 149 (01) :10-14

[8] HYPONATREMIA DURING OXCARBAZEPINE THERAPY [J].

PENDLEBURY, SC ;

MOSES, DK ;

EADIE, MJ .

HUMAN TOXICOLOGY, 1989, 8 (05) :337-344

[9] Recommendations on the clinical use of oxcarbazepine in the treatment of epilepsy:: a consensus view [J].

Schmidt, D ;

Arroyo, S ;

Baulac, M ;

Dam, M ;

Dulac, O ;

Friis, ML ;

Kälviäinen, R ;

Krämer, G ;

van Parys, J ;

Pedersen, B ;

Sachdeo, R .

ACTA NEUROLOGICA SCANDINAVICA, 2001, 104 (03) :167-170

[10]

VANAMELSVOORT T, 1994, EPILEPSIA, V35, P181