Serum Level of Mast Cell Tryptase in Patients with Oral Squamous Cell Carcinoma: Lack of Correlation with Clinicopathologic Factors

被引:3
作者
Jaafari-Ashkavandi, Zohreh [1 ]
Khademi, Bijan [2 ]
Akbari, Somayeh [3 ]
Malekzadeh, Mahyar [4 ]
机构
[1] Shiraz Univ Med Sci, Dept Oral & Maxillofacial Surg, Shiraz, Iran
[2] Shiraz Univ Med Sci, Inst Canc Res, Dept Otolaryngol & Head & Neck Surg, Shiraz, Iran
[3] Shiraz Univ Med Sci, Sch Dent, Shiraz, Iran
[4] Shiraz Univ Med Sci, Inst Canc Res, Shiraz, Iran
关键词
Mast cell; tryptase; serum; oral; head and neck; squamous cell carcinoma; ANGIOGENESIS; PROGNOSIS; RELEVANCE; CANCER;
D O I
10.7314/APJCP.2013.14.5.2955
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Mast cells can influence tumor progression via different pathways and increased mast cell density has been demonstrated in oral squamous cell carcinoma (OSCC). It has been shown that the serum tryptase level is elevated with some malignant tumours and may thus be a useful parameter. However, there are no data available about OSCC. The main aim of this study was the evaluation of mast cell tryptase (MCT) level in OSCC patient serum. Materials and Methods: In this cross-sectional, analytic study, the circulating levels of MCT were assessed in sera of 55 OSCC patients and 34 healthy individuals with ELISA technique. Results: The serum MCT level in OSCC patients was 12-14 ng/ml, which was not significantly higher than the healthy control group. While the serum level of MCT was higher with larger tumours, there was no apparent correlation with clinico-pathological features such as patient age, gender, tumor location, stage, nodal status, distant metastasis, histological grade and smoking. Conclusions: Our findings showed that despite the results obtained from studies of other malignant tumors, serum level of MCT in OSCC patients could not be a credited as a reliable indicator of the presence or progression of tumours.
引用
收藏
页码:2955 / 2958
页数:4
相关论文
共 28 条
[21]   The master switch: The role of mast cells in autoimmunity and tolerance [J].
Sayed, Blayne A. ;
Christy, Alison ;
Quirion, Mary R. ;
Brown, Melissa A. .
ANNUAL REVIEW OF IMMUNOLOGY, 2008, 26 :705-739
[22]   The Relevance of Mast Cells in Oral Squamous Cell Carcinoma [J].
Singh, Vineet ;
Ramesh, V. ;
Balamurali, P. D. .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2012, 6 (10) :1803-1807
[23]   Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia [J].
Sperr, WR ;
Jordan, JH ;
Baghestanian, M ;
Kiener, HP ;
Samorapoompichit, P ;
Semper, H ;
Hauswirth, A ;
Schernthaner, GH ;
Chott, A ;
Natter, S ;
Kraft, D ;
Valenta, R ;
Schwartz, LB ;
Geissler, K ;
Lechner, K ;
Valent, P .
BLOOD, 2001, 98 (07) :2200-2209
[24]   Crosstalk between Mast Cells and Pancreatic Cancer Cells Contributes to Pancreatic Tumor Progression [J].
Strouch, Matthew J. ;
Cheon, Eric C. ;
Salabat, Mohammad R. ;
Krantz, Seth B. ;
Gounaris, Elias ;
Melstrom, Laleh G. ;
Dangi-Garimella, Surabhi ;
Wang, Edward ;
Munshi, Hidayatullah G. ;
Khazaie, Khashayarsha ;
Bentrem, David J. .
CLINICAL CANCER RESEARCH, 2010, 16 (08) :2257-2265
[25]  
Tayebi-Meybodi N, 2007, IRAN J DERMATOL, V10, P135
[26]  
Tinge Beatrice, 2010, Cancer Genomics & Proteomics, V7, P25
[27]   Clinical and Laboratory Parameters of Mast Cell Activation as Basis for the Formulation of Diagnostic Criteria [J].
Valent, Peter ;
Horny, Hans-Peter ;
Triggiani, Massimo ;
Arock, Michel .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011, 156 (02) :119-127
[28]   Mast cell tryptase promotes breast cancer migration and invasion [J].
Xiang, Meng ;
Gu, Yiping ;
Zhao, Fengdi ;
Lu, Hong ;
Chen, Sifeng ;
Yin, Lianhua .
ONCOLOGY REPORTS, 2010, 23 (03) :615-619