Design and synthesis of gold-loaded micelles based on poly (ethylene glycol) and poly (4-vinyl pyridine) triblock copolymers for biomedical applications

被引：4

作者：

Bryaskova, R. ^{[1
]}

Vircheva, S. ^{[1
]}

Miloshev, S. ^{[1
]}

Dishovsky, N. ^{[1
]}

Tzoneva, R. ^{[2
]}

机构：

[1] Univ Chem Technol & Met, Dept Polymer Engn, 8 Kl Ohridski Blvd, BU-1756 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Acad G Bonchev Str,Bl 21, BU-1113 Sofia, Bulgaria

来源：

COLLOID AND POLYMER SCIENCE | 2017年 / 295卷 / 03期

关键词：

Block copolymers; Micelles; Gold nanoparticles; Cell viability; TRANSFER RADICAL POLYMERIZATION; TARGETED DRUG-DELIVERY; BLOCK-COPOLYMER; AMPHOTERICIN-B; NANOPARTICLES; CANCER; CYTOTOXICITY;

D O I：

10.1007/s00396-017-4025-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Gold-loaded micelles were prepared using triblock copolymers based on poly (ethylene glycol) and poly (4-vinyl pyridine) (P4VP-b-PEG-b-P4VP) obtained via atom transfer radical polymerization (ATRP). This was achieved using novel dichloro-terminated PEG as a macroinitiator. Further, ATRP was performed using 4-VP as a second forming block in the presence of CuCl/PMDETA as a catalyst system. The successful formation of P4VP-b-PEG-b-P4VP block copolymers was proved by FT-IR and H-1 NMR with the presence of all characteristic signals arising from PEG and 4-VP units. The self-assembling behavior of thus prepared block copolymer in an aqueous media was investigated. Further, gold nanoparticles were embedded into the P4VP core of the micelles. Cell viability of the gold-loaded micelles was proven by MTT test as they showed no cytotoxicity on cancerous and non-cancerous cells.

引用

页码：487 / 494

页数：8

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