Low-field He-3 nuclear magnetic resonance in human lungs

被引：45

作者：

Darrasse, L ^{[1
]}

Guillot, G ^{[1
]}

Nacher, PJ ^{[1
]}

Tastevin, G ^{[1
]}

机构：

[1] LAB KASTLER BROSSEL,CNRS,URA 18,F-75231 PARIS,FRANCE

来源：

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE B-MECANIQUE PHYSIQUE CHIMIE ASTRONOMIE | 1997年 / 324卷 / 11期

关键词：

D O I：

10.1016/S1251-8069(97)83175-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the first in vivo NMR experiments performed with hyperpolarised He-3 gas at 0.1 T. Hyperpolarisation is achieved by laser optical pumping of He-3 atoms in the metastable triplet state. Longitudinal relaxation times of nuclear magnetisation of the order of 35 s are measured in human lungs. Very long transverse relaxation times of a few seconds are also observed. This work establishes the possibility of magnetic resonance imaging of human lung airways at low field.

引用

页码：691 / 700

页数：10

共 28 条

[1]

ALBERT MS, 1994, NATURE, V370, P199, DOI 10.1038/370199a0

[2] Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized He-3 [J].

Bachert, P ;

Schad, LR ;

Bock, M ;

Knopp, MV ;

Ebert, M ;

Grossmann, T ;

Heil, W ;

Hofmann, D ;

Surkau, R ;

Otten, EW .

MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (02) :192-196

[3] NUCLEAR POLARIZATION IN HE-3 GAS INDUCED BY OPTICAL PUMPING AND DIPOLAR EXCHANGE [J].

BOUCHIAT, MA ;

CARVER, TR ;

VARNUM, CM .

PHYSICAL REVIEW LETTERS, 1960, 5 (08) :373-375

[4]

CAGNAC B, 1959, CR HEBD ACAD SCI, V249, P77

[5]

CALLAGHAN PT, 1991, PRINCIPLES NUCL MAGN, P217

[6] EFFECTS OF DIFFUSION ON FREE PRECESSION IN NUCLEAR MAGNETIC RESONANCE EXPERIMENTS [J].

CARR, HY ;

PURCELL, EM .

PHYSICAL REVIEW, 1954, 94 (03) :630-638

[7] A MATHEMATICAL-MODEL OF DIAMAGNETIC LINE BROADENING IN LUNG-TISSUE AND SIMILAR HETEROGENEOUS SYSTEMS - CALCULATIONS AND MEASUREMENTS [J].

CASE, TA ;

DURNEY, CH ;

AILION, DC ;

CUTILLO, AG ;

MORRIS, AH .

JOURNAL OF MAGNETIC RESONANCE, 1987, 73 (02) :304-314

[8] POLARIZATION OF HE3 GAS BY OPTICAL PUMPING [J].

COLEGROVE, FD ;

SCHEARER, LD ;

WALTERS, GK .

PHYSICAL REVIEW, 1963, 132 (06) :2561-&

[9]

CONSTANTINESCO A, 1997, MED NUCL IMAGERIE FO

[10] Nuclear magnetic resonance imaging with hyperpolarised helium-3 [J].

Ebert, M ;

Grossmann, T ;

Heil, W ;

Otten, WE ;

Surkau, R ;

Leduc, M ;

Bachert, P ;

Knopp, MV ;

Schad, LR ;

Thelen, M .

LANCET, 1996, 347 (9011) :1297-1299

← 1 2 3 →