Low-field He-3 nuclear magnetic resonance in human lungs

被引:44
作者
Darrasse, L [1 ]
Guillot, G [1 ]
Nacher, PJ [1 ]
Tastevin, G [1 ]
机构
[1] LAB KASTLER BROSSEL,CNRS,URA 18,F-75231 PARIS,FRANCE
来源
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE B-MECANIQUE PHYSIQUE CHIMIE ASTRONOMIE | 1997年 / 324卷 / 11期
关键词
D O I
10.1016/S1251-8069(97)83175-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We report the first in vivo NMR experiments performed with hyperpolarised He-3 gas at 0.1 T. Hyperpolarisation is achieved by laser optical pumping of He-3 atoms in the metastable triplet state. Longitudinal relaxation times of nuclear magnetisation of the order of 35 s are measured in human lungs. Very long transverse relaxation times of a few seconds are also observed. This work establishes the possibility of magnetic resonance imaging of human lung airways at low field.
引用
收藏
页码:691 / 700
页数:10
相关论文
共 28 条
  • [1] ALBERT MS, 1994, NATURE, V370, P199, DOI 10.1038/370199a0
  • [2] Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized He-3
    Bachert, P
    Schad, LR
    Bock, M
    Knopp, MV
    Ebert, M
    Grossmann, T
    Heil, W
    Hofmann, D
    Surkau, R
    Otten, EW
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (02) : 192 - 196
  • [3] NUCLEAR POLARIZATION IN HE-3 GAS INDUCED BY OPTICAL PUMPING AND DIPOLAR EXCHANGE
    BOUCHIAT, MA
    CARVER, TR
    VARNUM, CM
    [J]. PHYSICAL REVIEW LETTERS, 1960, 5 (08) : 373 - 375
  • [4] CAGNAC B, 1959, CR HEBD ACAD SCI, V249, P77
  • [5] CALLAGHAN PT, 1991, PRINCIPLES NUCL MAGN, P217
  • [6] EFFECTS OF DIFFUSION ON FREE PRECESSION IN NUCLEAR MAGNETIC RESONANCE EXPERIMENTS
    CARR, HY
    PURCELL, EM
    [J]. PHYSICAL REVIEW, 1954, 94 (03): : 630 - 638
  • [7] A MATHEMATICAL-MODEL OF DIAMAGNETIC LINE BROADENING IN LUNG-TISSUE AND SIMILAR HETEROGENEOUS SYSTEMS - CALCULATIONS AND MEASUREMENTS
    CASE, TA
    DURNEY, CH
    AILION, DC
    CUTILLO, AG
    MORRIS, AH
    [J]. JOURNAL OF MAGNETIC RESONANCE, 1987, 73 (02): : 304 - 314
  • [8] POLARIZATION OF HE3 GAS BY OPTICAL PUMPING
    COLEGROVE, FD
    SCHEARER, LD
    WALTERS, GK
    [J]. PHYSICAL REVIEW, 1963, 132 (06): : 2561 - &
  • [9] CONSTANTINESCO A, 1997, MED NUCL IMAGERIE FO
  • [10] Nuclear magnetic resonance imaging with hyperpolarised helium-3
    Ebert, M
    Grossmann, T
    Heil, W
    Otten, WE
    Surkau, R
    Leduc, M
    Bachert, P
    Knopp, MV
    Schad, LR
    Thelen, M
    [J]. LANCET, 1996, 347 (9011) : 1297 - 1299