Dimeric Approaches to Anti-Cancer Chemotherapeutics

被引：52

作者：

Hadden, M. K. ^{[1
]}

Blagg, B. S. J. ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 07期

关键词：

Anti-cancer; dimer; natural product dimers; synthetic dimers; bisintercalators;

D O I：

10.2174/187152008785914743

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Numerous proteins responsible for cell proliferation and differentiation exist either as hetero or homodimers or become activated through dimerization as a key step in their respective signaling cascade. Many of these proteins have been identified as major components in oncogenic signaling pathways and have become popular targets for the development of anti-tumor agents. For this reason, bivalent anti-cancer drugs that could potentially interact with each monomer of a dimeric protein target have been developed. This review provides a brief background on prevalent dimeric drug targets within the anti-cancer field and focuses mainly on dimeric natural product and synthetic cancer chemotherapeutics.

引用

收藏

页码：807 / 816

页数：10

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