Nanotechnology in the regulation of stem cell behavior

被引:19
作者
Wu, King-Chuen [1 ]
Tseng, Ching-Li [2 ]
Wu, Chi-Chang [2 ]
Kao, Feng-Chen [3 ]
Tu, Yuan-Kun [3 ]
So, Edmund C. [4 ]
Wang, Yang-Kao [2 ,5 ,6 ]
机构
[1] I Shou Univ, E Da Hosp, Dept Anesthesiol, Kaohsiung, Taiwan
[2] Taipei Med Univ, Grad Inst Biomed Mat & Tissue Engn, Taipei, Taiwan
[3] I Shou Univ, E Da Hosp, Dept Orthoped, Kaohsiung, Taiwan
[4] China Med Univ, Tainan Municipal An Nan Hosp, Dept Anesthesiol, Tainan, Taiwan
[5] Taipei Med Univ, Ctr Neurotrauma & Neuroregenerat, Taipei, Taiwan
[6] Natl Cheng Kung Univ, Med Device Innovat Ctr, Tainan 70101, Taiwan
关键词
stem cells; nanotechnology; nanotopography; cell adhesion; differentiation; OSTEOGENIC DIFFERENTIATION; BONE-MARROW; PROGENITOR CELLS; IN-VITRO; ADHESION; NANOPARTICLES; NANOFIBERS; THERAPY; SCAFFOLDS; NANOTOPOGRAPHY;
D O I
10.1088/1468-6996/14/5/054401
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Stem cells are known for their potential to repair damaged tissues. The adhesion, growth and differentiation of stem cells are likely controlled by the surrounding microenvironment which contains both chemical and physical cues. Physical cues in the microenvironment, for example, nanotopography, were shown to play important roles in stem cell fate decisions. Thus, controlling stem cell behavior by nanoscale topography has become an important issue in stem cell biology. Nanotechnology has emerged as a new exciting field and research from this field has greatly advanced. Nanotechnology allows the manipulation of sophisticated surfaces/scaffolds which can mimic the cellular environment for regulating cellular behaviors. Thus, we summarize recent studies on nanotechnology with applications to stem cell biology, including the regulation of stem cell adhesion, growth, differentiation, tracking and imaging. Understanding the interactions of nanomaterials with stem cells may provide the knowledge to apply to cell-scaffold combinations in tissue engineering and regenerative medicine.
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页数:11
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