Intravenous Artesunate for Transfusion-Transmitted Plasmodium vivax Malaria in a Preterm Neonate

被引:6
|
作者
Prashanth, Gowda Parameshwar [1 ,2 ]
Maralihalli, Mahesh B. [2 ]
Bagalkot, Praveen S. [2 ]
Joshi, Suhas N. [2 ]
机构
[1] KLE Univ, Jawaharlal Nehru Med Coll, Dept Pediat, Belgaum 590010, Karnataka, India
[2] SDM Coll Med Sci & Hosp Dharwad, Dept Pediat, Dharwad, Karnataka, India
关键词
artesunate; neonatal malaria; transfusion-transmitted malaria; Plasmodium vivax; FALCIPARUM-MALARIA; ORAL ARTESUNATE; UNITED-STATES; RISK; BLOOD; NEUTROPENIA; CHILDREN;
D O I
10.1542/peds.2011-2023
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Transfusion-transmitted malaria (TTM) in neonates is rare. TTM can occur in both endemic and nonendemic areas because the current tests used to screen the donor blood for malaria are unreliable when there is low parasitemia. Malaria must be considered as an important differential diagnosis for neonatal sepsis after exchange transfusion. Management strategy in TTM in the neonatal period is not standardized; exchange transfusion is often considered. We used intravenous artesunate in a case of severe malaria caused by Plasmodium vivax in a 30-week preterm neonate after packed red blood cell transfusion on day 19 of life. This is the first clinical report of parenteral artesunate successfully used in the neonatal period. We emphasize the need for further investigation of the safety and efficacy of intravenous artesunate in the treatment of severe neonatal malaria. Pediatrics 2012; 130: e706-e709
引用
收藏
页码:E706 / E709
页数:4
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