Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?

被引：11
|
作者：
Li, Yueling [1 ,2 ]
Baker-Ericzen, Mary [3 ]
Ji, Ning [1 ,2 ]
Chang, Weili [1 ,2 ]
Guan, Lili [1 ,2 ]
Qian, Qiujin [1 ,2 ]
Zhang, Yujuan [4 ]
Faraone, Stephen V. [5 ,6 ]
Wang, Yufeng [1 ,2 ]
机构：
[1] Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
[2] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
[3] Rady Childrens Hosp, Child & Adolescent Serv Res Ctr, San Diego, CA USA
[4] Xinjiang Med Univ, Affiliated Hosp 2, Xinjiang, Henan, Peoples R China
[5] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA
[6] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA
来源：
PSYCHIATRY RESEARCH | 2013年 / 205卷 / 1-2期
关键词：
Dopamine D4 receptor (DRD4); Attention-deficit/hyperactivity disorder (ADHD); Longitudinal; Adult ADHD; Han Chinese; DEFICIT-HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DOPAMINE-D4 RECEPTOR GENE; TANDEM DUPLICATION POLYMORPHISM; 4 EUROPEAN POPULATIONS; PROMOTER REGION; CANDIDATE GENE; ASSOCIATION; METAANALYSIS; PREVALENCE;
D O I：
10.1016/j.psychres.2012.08.016
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects (n=193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：143 / 150
页数：8
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