Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?

被引：11
|
作者：
Li, Yueling [1 ,2 ]
Baker-Ericzen, Mary [3 ]
Ji, Ning [1 ,2 ]
Chang, Weili [1 ,2 ]
Guan, Lili [1 ,2 ]
Qian, Qiujin [1 ,2 ]
Zhang, Yujuan [4 ]
Faraone, Stephen V. [5 ,6 ]
Wang, Yufeng [1 ,2 ]
机构：
[1] Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
[2] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
[3] Rady Childrens Hosp, Child & Adolescent Serv Res Ctr, San Diego, CA USA
[4] Xinjiang Med Univ, Affiliated Hosp 2, Xinjiang, Henan, Peoples R China
[5] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA
[6] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA
来源：
PSYCHIATRY RESEARCH | 2013年 / 205卷 / 1-2期
关键词：
Dopamine D4 receptor (DRD4); Attention-deficit/hyperactivity disorder (ADHD); Longitudinal; Adult ADHD; Han Chinese; DEFICIT-HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DOPAMINE-D4 RECEPTOR GENE; TANDEM DUPLICATION POLYMORPHISM; 4 EUROPEAN POPULATIONS; PROMOTER REGION; CANDIDATE GENE; ASSOCIATION; METAANALYSIS; PREVALENCE;
D O I：
10.1016/j.psychres.2012.08.016
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects (n=193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：143 / 150
页数：8
相关论文
共 50 条
  • [1] ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample
    Kraemer, Ulrike M.
    Rojo, Nuria
    Schuele, Rebecca
    Cunillera, Toni
    Schoels, Ludger
    Marco-Pallares, Josep
    Cucurell, David
    Camara, Estela
    Rodriguez-Fornells, Antoni
    Muente, Thomas F.
    BMC NEUROSCIENCE, 2009, 10
  • [2] DAT1 and DRD4 genes involved in key dimensions of adult ADHD
    Hasler, R.
    Salzmann, A.
    Bolzan, T.
    Zimmermann, J.
    Baud, P.
    Giannakopoulos, P.
    Perroud, N.
    NEUROLOGICAL SCIENCES, 2015, 36 (06) : 861 - 869
  • [3] No association of the dopamine DRD4 receptor (DRD4) gene polymorphism with attention deficit hyperactivity disorder (ADHD) in the Irish population
    Hawi, Z
    McCarron, M
    Kirley, A
    Daly, G
    Fitzgerald, M
    Gill, M
    AMERICAN JOURNAL OF MEDICAL GENETICS, 2000, 96 (03): : 268 - 272
  • [4] The dopamine D4 receptor (DRD4) gene promoter in adult subjects with ADHD
    Eichhammer, Peter
    Laufkoetter, Rainer
    Sand, Philipp G.
    Frank, Elmar
    Stoertebecker, Petra
    Langguth, Berthold
    Hajak, Goeran
    PSYCHIATRISCHE PRAXIS, 2007, 34 : S6 - S7
  • [5] Association between DRD4 gene and performance of children with ADHD in a test of sustained attention
    Kieling, Christian
    Roman, Tatiana
    Doyle, Alysa E.
    Hutz, Mara Helena
    Rohde, Luis Augusto
    BIOLOGICAL PSYCHIATRY, 2006, 60 (10) : 1163 - 1165
  • [6] DRD4 VNTRs, observed stranger fear in preschoolers and later ADHD symptoms
    Pappa, Irene
    Mileva-Seitz, Viara R.
    Szekely, Eszter
    Verhulst, Frank C.
    Bakermans-Kranenburg, Marian J.
    Jaddoe, Vincent W. V.
    Hofman, Albert
    Tiemeier, Henning
    van Llzendoorn, Marinus H.
    PSYCHIATRY RESEARCH, 2014, 220 (03) : 982 - 986
  • [7] Sequence variants of the DRD4 gene in autism:: Further evidence that rare DRD4 7R haplotypes are ADHD specific
    Grady, DL
    Harxhi, A
    Smith, M
    Flodman, P
    Spence, MA
    Swanson, JM
    Moyzis, RK
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 136B (01) : 33 - 35
  • [8] The Dopamine Receptor D4 Gene (DRD4) Moderates Family Environmental Effects on ADHD
    Martel, Michelle M.
    Nikolas, Molly
    Jernigan, Katherine
    Friderici, Karen
    Waldman, Irwin
    Nigg, Joel T.
    JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 2011, 39 (01) : 1 - 10
  • [9] Genetic interaction analysis for DRD4 and DAT1 genes in a group of Mexican ADHD patients
    Martinez-Levy, Gabriela
    Diaz-Galvis, John
    Briones-Velasco, Magdalena
    Gomez-Sanchez, Ariadna
    De la Pena-Olvera, Francisco
    Sosa-Mora, Liz
    Palacios-Cruz, Lino
    Ricardo-Garcell, Josefina
    Reyes-Zamorano, Ernesto
    Cruz-Fuentes, Carlos
    NEUROSCIENCE LETTERS, 2009, 451 (03) : 257 - 260
  • [10] Is there a role for rare variants in DRD4 gene in the susceptibility for ADHD? Searching for an effect of allelic heterogeneity
    Tovo-Rodrigues, L.
    Rohde, L. A.
    Roman, T.
    Schmitz, M.
    Polanczyk, G.
    Zeni, C.
    Marques, F. Z. C.
    Contini, V.
    Grevet, E. H.
    Belmonte-de-Abreu, P.
    Bau, C. H. D.
    Hutz, M. H.
    MOLECULAR PSYCHIATRY, 2012, 17 (05) : 520 - 526
12345