Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey

被引:83
作者
Jones, Kyle B. [1 ]
Klein, Ophir D. [1 ,2 ,3 ]
机构
[1] Univ Calif San Francisco, Program Craniofacial & Mesenchymal Biol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pediat, Div Med Genet, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Orofacia Sci, Ctr Craniofacial Anomalies, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
cancer stem cell; invariant asymmetry; neutral drift; oral epithelial stem cell; population asymmetry; LABEL-RETAINING CELLS; SITE-SPECIFIC RECOMBINATION; TRANSIT AMPLIFYING CELLS; HAIR FOLLICLE; SIDE-POPULATION; STEM/PROGENITOR CELLS; PROGENITOR POPULATION; MOUSE TONGUE; IN-VITRO; EXPRESSION;
D O I
10.1038/ijos.2013.46
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine. The advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny overtime. When combined with advanced mathematical and statistical methods, stem cell division dynamics can be studied in new and exciting ways. Despite advances in a number of tissues, relatively little attention has been paid to stem cells in the oral epithelium. This review will focus on current knowledge about adult oral epithelial stem cells, paradigms in other epithelial stem cell systems that could facilitate new discoveries in this area and the potential roles of epithelial stem cells in oral disease.
引用
收藏
页码:121 / 129
页数:9
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