More Than One Ring to Bind Them All: Recent Insights into the Structure of the Axon

被引:10
作者
Gallo, Gianluca [1 ]
机构
[1] Temple Univ, Sch Med Philadelphia, Shriners Hosp Pediat Res Ctr, Dept Anat & Cell Biol, Philadelphia, PA 19140 USA
关键词
cortactin; dynamin; spectrin; adducin; septin; filopodia; filopodium; branching; sprouting; guidance; microtubules; NERVE GROWTH-FACTOR; NUCLEATING ARP2/3 COMPLEX; MYOSIN-II ACTIVITY; ACTIN ORGANIZATION; RHOA-KINASE; CONE; FILOPODIA; CYTOSKELETAL; TRANSPORT; MECHANISMS;
D O I
10.1002/dneu.22100
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This brief review outlines recent developments in the understanding of the ultrastructural organization of the axonal and growth cone actin filament cytoskeleton. A novel form of structural organization has arisen as a regulator of the actin cytoskeleton: ring-like structures. Rings may represent a conserved functional theme exhibited by diverse molecular systems and have implications for the understanding of the axon in development, maturity, and disease. (c) 2013 Wiley Periodicals, Inc. Develop Neurobiol 73:799-805, 2013
引用
收藏
页码:799 / 805
页数:7
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