Exceptional Selectivity in Cyclopropanation Reactions Catalyzed by Chiral Cobalt(II)-Porphyrin Catalysts

被引：141
|
作者：
Doyle, Michael P. [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 05期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
carbenes; cobalt; diazoacetates; enantioselectivity; porphyrinoids; HIGHLY ENANTIOSELECTIVE CYCLOPROPANATION; ASYMMETRIC CYCLOPROPANATION; OLEFIN AZIRIDINATION; COBALT; DIAZOACETATES; COMPLEXES; ALKENES; DERIVATIVES; STYRENES;
D O I：
10.1002/anie.200804940
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Toss the olefin into the porphyrin: The development of chiral cobalt(II)-porphyrin catalysts by straightforward coupling processes has made possible the additions of diazocarbonyl compounds to a broad spectrum of olefins to access functionalized cylopropanes. The cyclopropanation reactions demonstrate high product yields, exceptional diastereoselectivity, and excellent enantiocontrol. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：850 / 852
页数：3
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