Exceptional Selectivity in Cyclopropanation Reactions Catalyzed by Chiral Cobalt(II)-Porphyrin Catalysts

被引：143

作者：

Doyle, Michael P. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 05期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

carbenes; cobalt; diazoacetates; enantioselectivity; porphyrinoids; HIGHLY ENANTIOSELECTIVE CYCLOPROPANATION; ASYMMETRIC CYCLOPROPANATION; OLEFIN AZIRIDINATION; COBALT; DIAZOACETATES; COMPLEXES; ALKENES; DERIVATIVES; STYRENES;

D O I：

10.1002/anie.200804940

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Toss the olefin into the porphyrin: The development of chiral cobalt(II)-porphyrin catalysts by straightforward coupling processes has made possible the additions of diazocarbonyl compounds to a broad spectrum of olefins to access functionalized cylopropanes. The cyclopropanation reactions demonstrate high product yields, exceptional diastereoselectivity, and excellent enantiocontrol. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：850 / 852

页数：3

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