Spectroflourimetric assessment of UO22+ by the quenching of the fluorescence intensity of Clopidogrel embedded in PMMA matrix

A new fluorescent optical sensor for highly sensitive and selective assessment of UO22+ in aqueous samples was introduced. The response of the sensor is based on the fluorescence quenching of [( +)-(S)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-clpyridin-5(4H)-yl)acetatel (Clopidogrel) embedded in polymethylmethacrylate (PMMA) polymer by UO22+. The sensor displays; wide concentration range from 1.0 x 10(-9) to 4.0 x 10(-6) MOI L-1, limit of detection (LOD) and limit of quantification (LOQ) are 2.6 x 10(-10) and 7.8 x 10(-10) mol L-1, respectively with a relatively fast response time of less than 60 s. The present sensor was revealed good response characteristics with respect to stability, reproducibility, sensitive and selectivity. Also, the response and quenching mechanisms for the present sensor were discussed. (C) 2015 Elsevier B.V. All rights reserved.