The utility of enzymes in generating molecular diversity. Lipase mediated amidation of polybenzyl esters

被引：15

作者：

Adamczyk, M

Gebler, JC

Grote, J

机构：

[1] Department of Chemistry (D9NM), Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064-3500

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(97)00147-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The feasibility of using lipases, particularly Pseudomonas cepacia, for the synthesis of a diverse molecular library is demonstrated Twenty-six different compounds were synthesized via lipase-catalyzed reaction of a core diester substrate with several amine partners, resulting in formation of a library of amides which were identified using electrospray mass spectrometry. (C) 1997 Elsevier Science Ltd.

引用

页码：1027 / 1030

页数：4

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