Intranasal delivery of biotechnology-based therapeutics

被引：17
作者：
Patel, Dhrumi [1 ]
Patel, Bharvi [1 ]
Wairkar, Sarika [1 ]
机构：
[1] SVKMs NMIMS, Shobhaben Pratapbhai Patel Sch Pharm & Technol Ma, VL Mehta Rd, Mumbai 400056, Maharashtra, India
来源：
DRUG DISCOVERY TODAY | 2022年 / 27卷 / 12期
关键词：
Intranasal; Biotechnology; Growth factors; Stem cells; Monoclonal antibodies; Genes; Peptides; NERVE GROWTH-FACTOR; NANOSTRUCTURED LIPID CARRIERS; MOUSE MODEL; BRAIN DELIVERY; IN-VIVO; NANOPARTICLES; EFFICACY; INSULIN; DISEASE; SCLEROSIS;
D O I：
10.1016/j.drudis.2022.103371
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Biotechnology-based therapeutics include a wide range of products, such as recombinant hormones, stem cells, therapeutic enzymes, monoclonal antibodies, genes, vaccines, among others. The administration of these macromolecules has been studied via various routes. The nasal route is one of the promising routes of administration for biotechnology products owing to its easy delivery, the rich vascularity of the nasal mucosa, high absorption and targeted action. Several preclinical studies have been reported for nasal delivery of these products and many are at the clinical stage. This review focuses on biotechnology-based therapeutics administered via the intranasal route for treating various diseases.
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页数：11
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