Acyl-CoA: Cholesterol acyltransferase inhibitors from flex macropoda

被引：9

作者：

Im, KR

Jeong, TS

Kwon, BM

Baek, NI

Kim, SH

Kim, DK ^{[1
]}

机构：

[1] Woosuk Univ, Coll Pharm, Samrye 565701, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

[3] Kyung Hee Univ, Grad Sch Biotechnol, Suwon 449701, South Korea

[4] Kyung Hee Univ, Plant Metab Res Ctr, Suwon 449701, South Korea

[5] Kyung Hee Univ, Grad Sch EW Med Sci, Suwon 449701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2006年 / 29卷 / 03期

关键词：

Ilex macropoda; ACAT inhibitory activity; Lupeol; Betulin;

D O I：

10.1007/BF02969391

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twigs from flex macropoda were extracted with MeOH, and the concentrated extracts were partitioned with CH2Cl2, EtOAc, n-BuOH, and H2O. Repeated column chromatography of the CH2Cl2 fraction ultimately resulted in the isolation of two compounds, via activity-guided fractionation, using ACAT inhibitory activity measurements. According to the physico-chemical data, the chemical structures of these isolated compounds were identified as lupeol (1) and betulin (2). Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 mu M, respectively.

引用

页码：191 / 194

页数：4

共 16 条

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