An Update on the Prognostic and Predictive Serum Biomarkers in Metastatic Prostate Cancer

被引：53
作者：
Saxby, Helen [1 ]
Mikropoulos, Christos [1 ]
Boussios, Stergios [2 ,3 ]
机构：
[1] Royal Surrey Cty Hosp, St Lukes Canc Ctr, Guildford GU2 7XX, Surrey, England
[2] Medway NHS Fdn Trust, Windmill Rd, Gillingham ME7 5NY, Kent, England
[3] AELIA Org, 9th Km Thessaloniki Thermi, Thessaloniki 57001, Greece
来源：
DIAGNOSTICS | 2020年 / 10卷 / 08期
关键词：
serum biomarkers; metastatic prostate cancer; microRNA biomarkers; bone metabolism biomarkers; neuroendocrine biomarkers; metabolite biomarkers; BONE TURNOVER MARKERS; SKELETAL-RELATED EVENTS; CHROMOGRANIN-A; ABIRATERONE; RISK; PROGRESSION; SARCOSINE; MICRORNA; 1ST;
D O I：
10.3390/diagnostics10080549
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Serum biomarkers are molecules produced by normal and abnormal cells. Prostate specific antigen (PSA) is an example of a serum biomarker used widely in the diagnosis and prognostication of prostate cancer. PSA has its limitations as it is organ- but not cancer-specific. The aim of this review is to summarize the current published data on the potential prognostic and predictive biomarkers in metastatic prostate cancer (mPC) that can be used in conjunction with PSA. These biomarkers include microRNAs, androgen receptor variants, bone metabolism, neuroendocrine and metabolite biomarkers, and could guide treatment selection and sequence in an era where we strive to personalized therapy.
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页数：10
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