Unraveling the physiological functions of exosome secretion by tumors

被引：35

作者：

Bobrie, Angelique

Thery, Clotilde ^{[1
]}

机构：

[1] Inst Curie, Sect Rech, Paris, France

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 01期

关键词：

exosomes; extracellular vesicles; Rab27a; tumor immunity; MECHANISMS; ANTIGEN;

D O I：

10.4161/onci.22565

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To understand the physiological functions of exosomes, we have recently used the inhibition of Rab27a, which prevents exosome release but also alters other secretion pathways. Our work demonstrates that the secretion of exosomes by some tumors in vivo can influence the immune microenvironment to promote tumor progression, but also that this phenomenon cannot be generalized to all tumors and all exosomes.

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