Incidence and clinical features of Clostridium difficile infection in Korea: a nationwide study

被引：45

作者：

Kim, Y. S. ^{[2
]}

Han, D. S. ^{[1
]}

Kim, Y. H. ^{[3
]}

Kim, W. H. ^{[4
]}

Kim, J. S. ^{[5
]}

Kim, H. S. ^{[6
,7
]}

Park, Y. S. ^{[8
]}

Song, H. J. ^{[9
]}

Shin, S. J. ^{[10
]}

Yang, S. K. ^{[11
]}

Ye, B. D. ^{[11
]}

Eun, C. S. ^{[1
]}

Lee, K. M. ^{[12
]}

Lee, S. H. ^{[2
]}

Jang, B. I. ^{[13
]}

Jung, S. A. ^{[14
]}

Cheon, J. H. ^{[4
]}

Choi, C. H. ^{[15
]}

Huh, K. C. ^{[16
]}

机构：

[1] Hanyang Univ, Coll Med, Dept Internal Med, Guri Si 471701, Gyunggi Do, South Korea

[2] Inje Univ, Coll Med, Dept Internal Med, Gyeongnam, South Korea

[3] Sungkyunkwan Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120749, South Korea

[5] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea

[6] Chonnam Natl Univ, Sch Med, Dept Internal Med, Kwangju, South Korea

[7] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Seoul 120749, South Korea

[8] Eulji Univ, Coll Med, Dept Internal Med, Taejon, South Korea

[9] Jeju Natl Univ, Sch Med, Dept Internal Med, Cheju, South Korea

[10] Ajou Univ, Sch Med, Dept Internal Med, Suwon 441749, South Korea

[11] Univ Ulsan, Coll Med, Dept Internal Med, Ulsan, South Korea

[12] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea

[13] Yeungnam Univ, Coll Med, Dept Internal Med, Taegu, South Korea

[14] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[15] Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[16] Konyang Univ, Coll Med, Dept Internal Med, Nonsan, South Korea

来源：

EPIDEMIOLOGY AND INFECTION | 2013年 / 141卷 / 01期

关键词：

Clostridium difficile infection; incidence; Korea; PSEUDOMEMBRANOUS COLITIS; VARIANT STRAIN; DIARRHEA; TOXIN; HOSPITALS; EPIDEMIOLOGY; MULTICENTER; PREVALENCE; MORTALITY; DIAGNOSIS;

D O I：

10.1017/S0950268812000581

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The incidence and severity of Clostridium difficile infections (CDI) have increased in Western countries. However, there are limited data regarding the epidemiology of CDI in Eastern countries. This nationwide study was conducted in 17 hospitals to determine temporal trends in CDI incidence (from 2004 to 2008) in South Korea. The total incidence of CDI in Korea was 1.7 cases/1000 adult admissions in 2004, and 2.7/1000 cases in 2008 (P=0.028). When analysing the clinical features of 1367 CDI patients diagnosed in 2008, oral metronidazole was effective as a first-line treatment for CDI (61.9%). Relapse rate was 8.9% and complicated CDI was only observed in 3.6%. The incidence of CDI increased significantly in Korea from 2004 to 2008. Although the clinical features were milder than in Western countries, the increasing burden of CDI needs ongoing surveillance systems.

引用

页码：189 / 194

页数：6

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