Electrochemical detection of celecoxib at a polyaniline grafted multiwall carbon nanotubes modified electrode

A modified electrode is fabricated by grafting polyaniline (PANI) chains onto multiwall carbon nanotubes (MWNTs) and utilized for the adsorptive reduction of celecoxib (CEL). PANI-g-MWNTs modified electrode appreciably enhances the sensitive detection of CEL in extremely lower concentrations (1 x 10(-11) M). Square wave stripping voltammogram (SWSV) shows a reduction peak at -1.08V with a high peak current for SW frequency of 100 Hz, amplitude of 25 mV and step height of 6 mV. The high surface area of PANI-g-MWNTs is effectively utilized for the adsorption of CEL to preconcentrate at the electrode, The PANI chains covalently linked to MWNTs mediate the electron transfer processes. The present finding open-up the scope for extending on the use of other conducting polymers grafted MWNTs modified electrodes for the detection of compounds that do not have surface-active properties at conventional electrodes. (C) 2008 Elsevier B.V. All rights reserved.