Three-component one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in 2,2,2-trifluoroethanol

被引：24

作者：

Khaksar, Samad ^{[1
]}

Talesh, Saeed Mohammadzadeh ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Ayatollah Amoli Branch, Amol, Iran

来源：

COMPTES RENDUS CHIMIE | 2012年 / 15卷 / 09期

关键词：

Quinazolin-4(1H)-one; Fluorinated solvent; Isatoic anhydride; Reusable; ELECTROPHILIC ACTIVATION; FLUORINATED ALCOHOLS; SELECTIVE OXIDATION; EFFICIENT SYNTHESIS; METAL-FREE; CATALYST; QUINAZOLIN-4(3H)-ONES; 4(3H)-QUINAZOLINONES; ALDEHYDES; KETONES;

D O I：

10.1016/j.crci.2012.05.019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trifluoroethanol (TFE) is found to be an efficient and recyclable medium in promoting one-pot, three-component coupling reactions of isatoic anhydride, aldehyde and ammonium acetate or primary amine to afford the corresponding 2,3-dihydroquinazolin-4(1H)-one derivatives in high yields. The solvent (TFE) can be readily separated from reaction products and recovered in excellent purity for direct reuse. (C) 2012 Published by Elsevier Masson SAS on behalf of Academie des sciences.

引用

页码：779 / 783

页数：5

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