Radiation grafting of glycidyl methacrylate onto cotton gauzes for functionalization with cyclodextrins and elution of antimicrobial agents

被引:27
作者
Hiriart-Ramirez, Erick [2 ]
Contreras-Garcia, Angel [3 ]
Jose Garcia-Fernandez, Maria [1 ]
Concheiro, Angel [1 ]
Alvarez-Lorenzo, Carmen [1 ]
Bucio, Emilio [2 ]
机构
[1] Univ Santiago de Compostela, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15782, Spain
[2] Univ Nacl Autonoma Mexico, Dept Quim Radiac & Radioquim, Inst Ciencias Nucl, Mexico City 04510, DF, Mexico
[3] Ecole Polytech, Dept Engn Phys, Montreal, PQ H3C 3A7, Canada
关键词
Cotton gauze; Glycidyl methacrylate; Drug delivery; Radiation grafting; Medical device; Cyclodextrin; Antimicrobial activity; MOLECULAR RECOGNITION; NALIDIXIC-ACID; DRUG-DELIVERY; CELLULOSE; FABRICS; IMMOBILIZATION; ANTIBACTERIAL; HEMICELLULOSE; POLYETHYLENE; PARAMETERS;
D O I
10.1007/s10570-012-9782-5
中图分类号
TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];
学科分类号
0805 ; 080502 ; 0822 ;
摘要
The aim of this work was to functionalize cotton gauzes with cyclodextrins in order to endow them with the ability to elute antimicrobial agents and to prevent infections. Gauzes were modified according to a two-steps approach: (1) pre-irradiation of the gauzes (Gammabeam) to graft glycidyl methacrylate (GMA), and (2) covalent binding of cyclodextrins (CDs) to the GMA-grafted gauzes. First the dependence of GMA grafting yield on the radiation dose (from 1 to 20 kGy) and the time of reaction was evaluated in detail. Anchorage of beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was confirmed by FTIR, TGA, and 3-methylbenzoic acid sorption. Differently from pristine gauzes, CD-functionalized GMA-grafted gauzes were able to load an anionic antibiotic drug, specifically nalidixic acid, and to sustain the release for 6 h. Drug-loaded gauzes were tested in vitro against E. coli and the results prove the suitability of the functionalization approach to efficiently inhibit the growth of this microorganism.
引用
收藏
页码:2165 / 2177
页数:13
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