Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions

被引：21
作者：
Kamimura, Kenya [1 ]
Yokoo, Takeshi [1 ]
Abe, Hiroyuki [1 ]
Kobayashi, Yuji [1 ]
Ogawa, Kohei [1 ]
Shinagawa, Yoko [1 ]
Inoue, Ryosuke [1 ]
Terai, Shuji [1 ]
机构：
[1] Niigata Univ, Grad Sch Med & Dent Sci, Div Gastroenterol & Hepatol, Niigata 9518510, Japan
来源：
PHARMACEUTICS | 2015年 / 7卷 / 03期
关键词：
gene therapy; hydrodynamics-based gene delivery; DNA; clinical application; LONG-TERM EXPRESSION; DIET-INDUCED OBESITY; HEPATITIS-B-VIRUS; IN-VIVO; RNA INTERFERENCE; GROWTH-FACTOR; CLINICAL-TRIALS; PROTECTS MICE; MOUSE MODEL; NAKED DNA;
D O I：
10.3390/pharmaceutics7030213
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application.
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收藏
页码：213 / 223
页数：11
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