Impact of early gut microbiota on immune and metabolic development and function

被引：88

作者：

Wang, Mei ^{[1
]}

Monaco, Marcia H. ^{[1
]}

Donovan, Sharon M. ^{[1
]}

机构：

[1] Univ Illinois, Dept Food Sci & Human Nutr, 339 Bevier Hall,905 S Goodwin Ave, Urbana, IL 61801 USA

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2016年 / 21卷 / 06期

关键词：

Gut microbiota; Immune system; Metabolism; Diet; Antibiotics; Cesarean section; HUMAN-MILK OLIGOSACCHARIDES; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL MICROBIOTA; COMMENSAL BACTERIA; NECROTIZING ENTEROCOLITIS; FECAL MICROBIOTA; PRETERM INFANTS; DELIVERY MODE; EARLY-LIFE; 1ST YEAR;

D O I：

10.1016/j.siny.2016.04.004

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Microbial colonization of the infant intestine occurs in the first two years of life. Symbiotic host and microbe interactions are critical for host metabolic and immune development. Emerging evidence indicates that early microbiota colonization may influence the occurrence of metabolic and immune diseases. Further understanding of the importance of environmental factors, including fetal microbial exposure, diet, delivery mode, pre- and probiotic consumption, and antibiotic use on immune and metabolic programming will provide new opportunities for the development of therapeutic and prophylactic measures to improve infant health and reduce the risk of disease in post -infancy years. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：380 / 387

页数：8

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