Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea

被引：53

作者：

Kim, You Ah ^{[6
]}

Kong, Chang-Suk ^{[5
]}

Lee, Jung Im ^{[1
]}

Kim, Hojun ^{[1
]}

Park, Hee Yeon ^{[2
]}

Lee, Hyi-Seung ^{[3
]}

Lee, Chulhyun ^{[4
]}

Seo, Youngwan ^{[1
]}

机构：

[1] Korea Maritime Univ, Div Marine Environm & Biosci, Pusan 606791, South Korea

[2] Natl Fisheries Res & Dev Inst, Food & Safety Res Ctr, Pusan 619705, South Korea

[3] Ocean Res & Dev Inst, Marine Nat Prod Chem Lab, Ansan 425600, South Korea

[4] Korea Basic Sci Inst, Magnet Resonance Team, Taejon 305333, South Korea

[5] Silla Univ, Coll Med & Life Sci, Dept Food & Nutr, Pusan 617736, South Korea

[6] Korea Promot Inst Tradit Med Ind, Nat Cpds Bank Estab Dept, Gyeongbuk 712260, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 13期

关键词：

Salicornia herbacea; Saponin; DPPH; Peroxynitrite; FREE-RADICALS;

D O I：

10.1016/j.bmcl.2012.05.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a part of an ongoing search for novel antioxidants from the salt marsh plants, bioactivity-isolation and structure determination of constituents from Salicornia herbacea were performed. One new triterpenoid saponin (4), along with three known saponins (1-3), has been isolated from n-BuOH fraction of S. herbacea. On the basis of the spectroscopic methods, the structure of the new saponin 4 was elucidated as 3 beta-hydroxy-23-oxo-30-noroleana-12, 20(29)-diene-28-oic acid 3-O-beta-D-glucuronopyranosyl-28-O-beta-D-glucopyranoside. Scavenging effects of saponins 1-4 were examined on 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical and peroxynitrite. Particularly, saponin 3 exerted significant antioxidant activity on both authentic peroxynitrite and peroxynitrite generated from morpholinosydnonimine (SIN-1). (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4318 / 4322

页数：5

共 33 条

[1] A saponin from the roots of Gypsophila bermejoi [J].

Acebes, B ;

Díaz-Lanza, AM ;

Bernabé, M .

PHYTOCHEMISTRY, 1998, 49 (07) :2077-2079

[2]

Amiri B., 2010, Caspian Journal of Environmental Sciences, V8, P79

[3] Oxidative and nitrative stress markers in glaucoma [J].

Aslan, Mutay ;

Cort, Aysegul ;

Yucel, Iclal .

FREE RADICAL BIOLOGY AND MEDICINE, 2008, 45 (04) :367-376

[4] MOLLUSCICIDAL SAPONINS FROM SWARTZIA-SIMPLEX [J].

BOREL, C ;

GUPTA, MP ;

HOSTETTMANN, K .

PHYTOCHEMISTRY, 1987, 26 (10) :2685-2689

[5] Free radicals in the physiological control of cell function [J].

Dröge, W .

PHYSIOLOGICAL REVIEWS, 2002, 82 (01) :47-95

[6] Boussingoside E, a new triterpenoid saponin from the tubers of Boussingaultia baselloides [J].

Espada, A ;

Riguera, R .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (01) :17-19

[7] Oxidant signals and oxidative stress [J].

Finkel, T .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) :247-254

[8] MECHANISM OF SALT TOLERANCE IN HALOPHYTES [J].

FLOWERS, TJ ;

TROKE, PF ;

YEO, AR .

ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1977, 28 :89-121

[9] Fluorescence probes used for detection of reactive oxygen species [J].

Gomes, A ;

Fernandes, E ;

Lima, JLFC .

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 2005, 65 (2-3) :45-80

[10] MECHANISMS OF SALT TOLERANCE IN NON-HALOPHYTES [J].

GREENWAY, H ;

MUNNS, R .

ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1980, 31 :149-190

← 1 2 3 4 →