Whole-body vibration and resistance exercise prevent long-term hindlimb unloading-induced bone loss: independent and interactive effects

被引：18

作者：

Li, Zhili ^{[1
,2
]}

Tan, Cheng ^{[2
]}

Wu, Yonghua ^{[3
]}

Ding, Ye ^{[4
]}

Wang, Huijuan ^{[2
]}

Chen, Wenjuan ^{[2
]}

Zhu, Yu ^{[2
]}

Ma, Honglei ^{[2
]}

Yang, Honghui ^{[2
]}

Liang, Wenbin ^{[5
]}

Jiang, Shizhong ^{[2
]}

Wang, Desheng ^{[2
]}

Wang, Linjie ^{[2
]}

Tang, Guohua ^{[2
]}

Wang, Jun ^{[6
]}

机构：

[1] Fourth Mil Med Univ, Sch Aerosp Med, Dept Aerosp Biodynam, Xian 710032, Peoples R China

[2] China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China

[3] Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China

[4] China Agr Univ, Dept Vet Pathol, Key Lab Zoonosis, Minist Agr,Coll Vet Med, Beijing 100193, Peoples R China

[5] Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

[6] Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Peoples R China

来源：

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY | 2012年 / 112卷 / 11期

关键词：

Bone loss; Whole-body vibration; Resistance exercise; Hindlimb unloading; RAPIDLY GROWING RATS; TAIL-SUSPENDED RATS; CORTICAL BONE; AMINOHYDROXYBUTANE BISPHOSPHONATE; SIMULATED WEIGHTLESSNESS; BIOCHEMICAL-PROPERTIES; POSTMENOPAUSAL WOMEN; MECHANICAL STIMULI; MUSCLE STRENGTH; MINERAL DENSITY;

D O I：

10.1007/s00421-012-2355-3

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Skeletal unloading induced by disuse or immobilization causes a decrease in bone mass and strength. We investigated the relationship between whole-body vibration (WBV) and resistance exercise (RE) in preventing bone loss induced by 8-week hindlimb unloading in young male rats. Sixty male Wistar rats were assigned randomly to 6 groups: age-matched control group (CON, n = 10), hindlimb unloading group (HU, n = 10), hindlimb unloading + standing group (HU + ST, n = 10), hindlimb unloading + WBV group (HU + WBV, n = 10), hindlimb unloading + RE group (HU + RE, n = 10) and hindlimb unloading + WBV + RE group (HU + WBV + RE, n = 10). After 8-week hindlimb unloading, micro-CT scanning and three-point bending test were performed in the femur. Sera were collected for analysis of bone formation and resorption markers. Compared with HU group, WBV, RE and the combination of WBV and RE (WBV + RE) significantly improved (P < 0.01) one repetition maximum (1RM) (expressed as the percentage change from baseline, HU: -23%, HU + WBV: 21%, HU + RE: 48%, HU + WBV + RE: 51%), and maintained (P < 0.05) cancellous volumetric bone mineral density (vBMD) and trabecular structure. No difference of cortical vBMD was found among all groups (P > 0.05). WBV had no effects on biomechanical properties of the femur diaphysis (P > 0.05). RE and WBV + RE significantly increased maximum load and cross-sectional moment of inertia of the femur diaphysis in hindlimb unloading rats (P < 0.05). There was an interaction between WBV and RE in improving cancellous bone. These results demonstrate that WBV and RE interactively maintain cancellous structure and vBMD, and independently partially mitigate the reduction of bone strength in long-term hindlimb unloading rats.

引用

页码：3743 / 3753

页数：11

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